DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ saitoh-2015-1 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. DIP original experiment: DIP-265348X Science (New York, N.Y.) 2015 IMEx Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. Only protein-protein interactions imex curation saitoh-2015-2 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. DIP original experiment: DIP-265349X Science (New York, N.Y.) 2015 IMEx Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. Only protein-protein interactions imex curation saitoh-2015-3 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. DIP original experiment: DIP-265350X Science (New York, N.Y.) 2015 IMEx Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Saitoh Y., Suzuki H., Tani K., Nishikawa K., Irie K., Ogura Y., Tamura A., Tsukita S., Fujiyoshi Y. Only protein-protein interactions imex curation cld19_mouse Claudin-19 Cldn19 protein protein mouse Mus musculus Mouse MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKSRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLCCTCPEPERANSIPQPYRSGPSTAAREPVVKLPASVKGPLGV mint Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity eltb_clopf Heat-labile enterotoxin B chain cpe protein protein clostridium perfring Clostridium perfringens MLSNNLNPMVFENAKEVFLISEDLKTPINITNSNSNLSDGLYVIDKGDGWILGEPSVVSSQILNPNETGTFSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQAIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLNLTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGDGVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF cld3_mouse Claudin-3 Cldn3 Cpetr2 Clostridium perfringens enterotoxin receptor 2 protein protein mouse Mus musculus Mouse MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPLVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPRDKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV mint Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity cldn19-cpe-1 3275344 N/A 3275347 unspecified role unspecified role unspecified role unspecified role Q9ET38:p.Asn150Leu N150L/D/K/Q/S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile41Ser I41S/V mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile40Ser I40S/V/L mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ala39Arg A39R/S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Tyr35Ser Y35S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Tyr159Ser Y159S/F mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Pro154Asp P154D mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Asn156Gly N156G mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ser152Asp S152D mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Thr153Tyr T153Y mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Pro151Gly P151G mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile40Ala I40A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile41Ala I41A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Pro154Ala P154A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Asn150Ala N150A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Pro151Ala P151A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ala39Ser mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Asn150Asp mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Asn150Lys mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Asn150Gln mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Asn150Ser mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile41Val mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile40Val mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Ile40Leu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false Q9ET38:p.Tyr159Phe mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm N/A 3275348 unspecified role unspecified role unspecified role unspecified role Region 194-319 Region 194-319 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false cldn3-cpe-1 3275345 N/A 3275349 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm N/A 3275348 unspecified role unspecified role unspecified role unspecified role Region 194-319 Region 194-319 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false cldn19-cpe-2 3275346 N/A 3275347 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm N/A 3275348 unspecified role unspecified role unspecified role unspecified role Region 203-319 Region 203-319 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false