DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ marsolier-2015-1 bovin Bos taurus (Bovine) Bovine anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265508X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions imex curation marsolier-2015-2 bovin Bos taurus (Bovine) Bovine anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265503X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions imex curation marsolier-2015-3 bovin Bos taurus (Bovine) Bovine pull down pull down western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265506X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions imex curation marsolier-2015-4 bovin Bos taurus (Bovine) Bovine anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265504X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions imex curation marsolier-2015-5 bovin Bos taurus (Bovine) Bovine pull down pull down predetermined predetermined participant predetermined Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265507X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions imex curation marsolier-2015-6 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265505X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions imex curation fbxw7_human F-box/WD repeat-containing protein 7 FBXW7 FBW7 FBX30 SEL10 F-box and WD-40 domain-containing protein 7 F-box protein FBX30 Archipelago homolog SEL-10 hCdc4 protein protein human Homo sapiens Human MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK pin1_thean Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 Peptidyl-prolyl cis-trans isomerase Pin1 Rotamase Pin1 TA18945 protein protein thean Theileria annulata MIRNFLNFLWNNTSLRFLIINTIIFAMDKVRCAHLLLKHTGSRNPVNRNTGMAVTRTKEEAVSEMKGYLEMLRKSDNLDQEFRRLATAKSECSSARKGGDLGFFDRNTMQKPFTEASFKLEVNEISDLVETDSGVHLIYRIA ubiq_bovin Ubiquitin RPS27A UBA80 UBCEP1 UBA52 UBCEP2 UBB UBC protein protein bovin Bos taurus (Bovine) Bovine MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG jun_bovin Transcription factor AP-1 JUN Activator protein 1 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog protein protein bovin Bos taurus (Bovine) Bovine MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGLVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGSLSSGGGAPSYGAAGLAFPAQPQQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF fbxw7_bovin F-box/WD repeat-containing protein 7 FBXW7 FBW7 F-box and WD-40 domain-containing protein 7 protein protein bovin Bos taurus (Bovine) Bovine MNQELLSVGSKRRRTGGSLRGNPSSSQADEEQMNRVLEEEQQQPRHQEEEHAARNGEVVGAEPRPGDQNDPQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHRNSVTNSNSIVDLPIHQRSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK pin1_human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Rotamase Pin1 Peptidyl-prolyl cis-trans isomerase Pin1 PIN1 protein protein human Homo sapiens Human MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE fbxw7_mouse F-box/WD repeat-containing protein 7 Fbxw7 Fbw7 Fbwd6 Fbxw6 F-box and WD-40 domain-containing protein 7 F-box protein FBW7 F-box protein Fbxw6 F-box-WD40 repeat protein 6 SEL-10 protein protein mouse Mus musculus Mouse MNQELLSVGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQARHQEEEHTARNGELVGANPRPGDQNDTQQGQVEENNNRFISVDEDSSGNQEEQEEDEEHAGEQEEEEEEEEEEEEMDQESDDFDPSDDSSREDEHTHNSNVTNCSSVSDLPAHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 mint fbxw7-pin1-1 3274843 N/A 3274849 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false bovin Bos taurus (Bovine) Bovine N/A 3274850 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine physical association physical association false false false jun-bub-1 3274844 N/A 3274851 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine N/A 3274852 unspecified role unspecified role bait bait bovin Bos taurus (Bovine) Bovine physical association physical association false false false pin1-fbxw7-1 3274845 N/A 3274853 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine N/A 3274850 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli physical association physical association false false false fbxw7-bub-1 3274846 N/A 3274853 unspecified role unspecified role bait bait bovin Bos taurus (Bovine) Bovine N/A 3274851 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine physical association physical association false false false pin1-fbxw7-2 3274847 N/A 3274854 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3274853 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine physical association physical association false false false pin1-fbxw7-3 3274848 N/A 3274855 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3274850 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false mouse Mus musculus Mouse physical association physical association false false false