DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ magin-2015-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Magin RS., Liszczak GP., Marmorstein R. DIP original experiment: DIP-264766X Structure (London, England : 1993) 2015 IMEx The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. Magin RS., Liszczak GP., Marmorstein R. Only protein-protein interactions imex curation magin-2015-2 in vitro In vitro acetylase assay acetylase assay predetermined predetermined participant predetermined Magin RS., Liszczak GP., Marmorstein R. DIP original experiment: DIP-264767X Structure (London, England : 1993) 2015 IMEx The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. Magin RS., Liszczak GP., Marmorstein R. Only protein-protein interactions imex curation magin-2015-3 in vitro In vitro acetylase assay acetylase assay predetermined predetermined participant predetermined Magin RS., Liszczak GP., Marmorstein R. DIP original experiment: DIP-264768X Structure (London, England : 1993) 2015 IMEx The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. Magin RS., Liszczak GP., Marmorstein R. Only protein-protein interactions imex curation h4_human Histone H4 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H4 HIST2H4A HIST2H4B HIST4H4 protein protein human Homo sapiens Human MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG q86uy6-1 N-alpha-acetyltransferase 40 NAA40 NAT11 PATT1 N-acetyltransferase 11 N-alpha-acetyltransferase D Protein acetyltransferase 1 protein protein human Homo sapiens Human MGRKSSKAKEKKQKRLEERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGLEPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSHHSHAGGHCGGCCH hist1h4a-naa40-1 3274765 N/A 3274768 unspecified role unspecified role unspecified role unspecified role Region 2-6 Region 2-6 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3274769 unspecified role unspecified role unspecified role unspecified role Region 17-220 Region 17-220 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false hist1h4a-naa40-2 3274766 N/A 3274768 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 2-20 Region 2-20 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3274769 enzyme enzyme unspecified role unspecified role Q86UY6-1:p.Tyr85Ala Y85A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Trp90Ala W90A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Glu100Ala E100A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.[Asp127Ala;Glu129Ala] Q127A/E129A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Tyr136Ala Y136A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Tyr136Phe Y136F mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Cys137Ala C137A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Tyr138Ala Y138A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Glu139Ala E139A mutation decreasing rate mutation decreasing interaction rate mutation decreasing rate alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false Q86UY6-1:p.Glu139Gln E139Q mutation disrupting rate mutation disrupting interaction rate mutation disrupting rate substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli acetylation acetylation reaction acetylation false false false hist1h4a-naa40-3 3274767 N/A 3274768 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 2-6 Region 2-6 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3274769 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli acetylation acetylation reaction acetylation false false false