DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ zhang-2015-20 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. DIP original experiment: DIP-265259X Nature 2015 IMEx Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. Only protein-protein interactions imex curation zhang-2015-21 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. DIP original experiment: DIP-265260X Nature 2015 IMEx Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. Only protein-protein interactions imex curation zhang-2015-22 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. DIP original experiment: DIP-265261X Nature 2015 IMEx Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. Only protein-protein interactions imex curation ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG ubp18_human Ubl carboxyl-terminal hydrolase 18 USP18 ISG43 ISG15-specific-processing protease 43 kDa ISG15-specific protease Ubl thioesterase 18 protein protein human Homo sapiens Human MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC q13309-1 S-phase kinase-associated protein 2 Cyclin-A/CDK2-associated protein p45 F-box protein Skp2 F-box/LRR-repeat protein 1 p45skp2 SKP2-alpha SKP2 FBXL1 protein protein human Homo sapiens Human MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL isg15_human Ubiquitin-like protein ISG15 ISG15 G1P2 UCRP Interferon-induced 15 kDa protein Interferon-induced 17 kDa protein Ubiquitin cross-reactive protein protein protein human Homo sapiens Human MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGGGTEPGGRS usp18-ub-1 3270471 N/A 3270474 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false human Homo sapiens Human N/A 3270475 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false usp18-skp2-1 3270472 N/A 3270476 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3270475 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false usp18-isg15-4 3270473 N/A 3270477 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3270475 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false