DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ fischer-2014-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. DIP original experiment: DIP-262051X Nature 2014 IMEx Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. Only protein-protein interactions imex curation fischer-2014-2 in vitro In vitro comigration in sds comigration in sds page comigration in sds predetermined predetermined participant predetermined Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. DIP original experiment: DIP-262052X Nature 2014 IMEx Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. Only protein-protein interactions imex curation fischer-2014-3 in vitro In vitro comigration in sds comigration in sds page comigration in sds western blot western blot Immuno blot Immuno blot Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. DIP original experiment: DIP-262053X Nature 2014 IMEx Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. Only protein-protein interactions imex curation crbn_chick Protein cereblon CRBN protein protein chick Gallus gallus (Chicken) Chicken MAAEEGGDGRRNMGNPPPPAPAESEEEDDNEMEVEDQDGKEAEKPNMINFDTSLPTSHMYLGSDMEEFHGRTLHDDDSCQVIPVLPHVMVMLIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVREREAHFGTTAEIYAYREEQEYGIETVKVKAIGRQRFKVLEIRTQSDGIQQAKVQILPERVLPSTMSAVQLQSLSRRHIFPSSKPKVWQDRAFRQWWQKYQKRKFHCASLTSWPPWLYSLYDAETLMERVKRQLHEWDENLKDESLPTNPIDFSYRVAACLPIDDALRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQDTEITTKNEIFSLSLCGPMAAYVNPHGYIHETLTVYKACNLNLSGRPSTEHSWFPGYAWTIAQCRICGNHMGWKFTATKKDMSPQKFWGLTRSALLPRIPEAEDELGHDRSPLLCL ddb1_human DNA damage-binding protein 1 DDB1 Damage-specific DNA-binding protein 1 UV-damaged DNA-binding factor DDB p127 subunit DNA damage-binding protein a UV-damaged DNA-binding protein 1 Xeroderma pigmentosum group E-complementing protein XPE-binding factor HBV X-associated protein 1 XAP1 protein protein human Homo sapiens Human MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG crbn_human Protein cereblon CRBN AD-006 protein protein human Homo sapiens Human MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL meis2_human Homeobox protein Meis2 MRG1 Meis1-related protein 1 MEIS2 protein protein human Homo sapiens Human MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ crbn-ddb1-5 3268091 N/A 3268094 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper N/A 3268095 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction false false false crbn-ub-1 3268092 N/A 3268096 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3268097 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction false false false meis2-ub-1 3268093 N/A 3268098 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper N/A 3268096 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false