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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
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            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3263016">
                <names>
                    <shortLabel>newton-2014-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="24557836" refType="primary-reference" refTypeAc="MI:0358"/>
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                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-264649X" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10090">
                        <names>
                            <shortLabel>mouse</shortLabel>
                            <fullName>Mus musculus</fullName>
                            <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Newton K., Dugger DL., Wickliffe KE., Kapoor N., de Almagro MC., Vucic D., Komuves L., Ferrando RE., French DM., Webster J., Roose-Girma M., Warming S., Dixit VM.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-264649X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Science (New York, N.Y.)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2014</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Newton K.,  Dugger DL.,  Wickliffe KE.,  Kapoor N.,  de Almagro MC.,  Vucic D.,  Komuves L.,  Ferrando RE.,  French DM.,  Webster J.,  Roose-Girma M.,  Warming S.,  Dixit VM.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="3263017">
                <names>
                    <shortLabel>newton-2014-2</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="24557836" refType="primary-reference" refTypeAc="MI:0358"/>
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                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-264650X" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24119" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10090">
                        <names>
                            <shortLabel>mouse</shortLabel>
                            <fullName>Mus musculus</fullName>
                            <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
                    </names>
                    <xref>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Newton K., Dugger DL., Wickliffe KE., Kapoor N., de Almagro MC., Vucic D., Komuves L., Ferrando RE., French DM., Webster J., Roose-Girma M., Warming S., Dixit VM.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-264650X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Science (New York, N.Y.)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2014</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Newton K.,  Dugger DL.,  Wickliffe KE.,  Kapoor N.,  de Almagro MC.,  Vucic D.,  Komuves L.,  Ferrando RE.,  French DM.,  Webster J.,  Roose-Girma M.,  Warming S.,  Dixit VM.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3263018">
                <names>
                    <shortLabel>casp8_mouse</shortLabel>
                    <fullName>Caspase-8</fullName>
                    <alias typeAc="MI:0301" type="gene name">Casp8</alias>
                </names>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP</sequence>
            </interactor>
            <interactor id="3263019">
                <names>
                    <shortLabel>ripk3_mouse</shortLabel>
                    <fullName>Receptor-interacting serine/threonine-protein kinase 3</fullName>
                    <alias typeAc="MI:0301" type="gene name">Ripk3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Rip3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RIP-like protein kinase 3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Receptor-interacting protein 3</alias>
                </names>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_176"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033077" secondary="T cell differentiation in thymus" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_176"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4M66" version="SP_176"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-937041" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051353" secondary="positive regulation of oxidoreductase activity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_176"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR025735" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001914" secondary="regulation of T cell mediated cytotoxicity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000452" secondary="regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010922" secondary="positive regulation of phosphatase activity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004704" secondary="NF-kappaB-inducing kinase activity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046006" secondary="regulation of activated T cell proliferation" version="SP_176"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JPD" version="SP_176"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6116401" refType="intact-secondary"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-3295583" version="SP_176"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8K2Y2" version="SP_113" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2367423" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051351" secondary="positive regulation of ligase activity" version="SP_176"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000022830" version="SP_176" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5213460" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042981" secondary="regulation of apoptotic process" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048538" secondary="thymus development" version="SP_176"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_176"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2562578" version="SP_176"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="G3X8V8" version="SP_113" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060545" secondary="positive regulation of necroptotic process" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097300" secondary="programmed necrotic cell death" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990000" secondary="amyloid fibril formation" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048535" secondary="lymph node development" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032649" secondary="regulation of interferon-gamma production" version="SP_176"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_064339.2"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5675482" version="SP_176"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000022221" version="SP_176" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097527" secondary="necroptotic signaling pathway" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001244" secondary="positive regulation of intrinsic apoptotic signaling pathway" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070235" secondary="regulation of activation-induced cell death of T cells" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002819" secondary="regulation of adaptive immune response" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" secondary="signal transduction" version="SP_176"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3U3Z9" version="SP_113" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070301" secondary="cellular response to hydrogen peroxide" version="SP_176"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-54883N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" secondary="protein autophosphorylation" version="SP_176"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_176"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4M69" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032147" secondary="activation of protein kinase activity" version="SP_176"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_176"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6OKO" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000377" secondary="regulation of reactive oxygen species metabolic process" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070266" secondary="necroptotic process" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000379" secondary="positive regulation of reactive oxygen species metabolic process" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051607" secondary="defense response to virus" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007249" secondary="I-kappaB kinase/NF-kappaB signaling" version="SP_176"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048536" secondary="spleen development" version="SP_176"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRSSGRNLSAREPSQRGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPERQAQDTSVGPATPARTSSDPVAGTPQIPHTLPFRGTTPGPVFTETPGPHPQRNQGDGRHGTPWYPWTPPNPMTGPPALVFNNCSEVQIGNYNSLVAPPRTTASSSAKYDQAQFGRGRGWQPFHK</sequence>
            </interactor>
            <interactor id="3263020">
                <names>
                    <shortLabel>ripk1_mouse</shortLabel>
                    <fullName>Receptor-interacting serine/threonine-protein kinase 1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Cell death protein RIP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Receptor-interacting protein 1</alias>
                    <alias typeAc="MI:0301" type="gene name">Ripk1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Rinp</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Rip</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q60855" version="SP_78" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901026" secondary="ripoptosome assembly involved in necroptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036289" secondary="peptidyl-serine autophosphorylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070301" secondary="cellular response to hydrogen peroxide" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050729" secondary="positive regulation of inflammatory response" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010940" secondary="positive regulation of necrotic cell death" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000167374" version="SP_204" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000377" secondary="regulation of reactive oxygen species metabolic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070926" secondary="regulation of ATP:ADP antiporter activity" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000021844" version="SP_204" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-3371378" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070105" secondary="positive regulation of interleukin-6-mediated signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097527" secondary="necroptotic signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044257" secondary="cellular protein catabolic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043123" secondary="positive regulation of I-kappaB kinase/NF-kappaB signaling" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043124" secondary="negative regulation of I-kappaB kinase/NF-kappaB signaling" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" secondary="inflammatory response" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032760" secondary="positive regulation of tumor necrosis factor production" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070513" secondary="death domain binding" version="SP_204"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_033094.3"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5213460" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990000" secondary="amyloid fibril formation" version="SP_204"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-529119" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-34962N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008219" secondary="cell death" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037934" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097300" secondary="programmed necrotic cell death" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3U0J3" version="SP_78" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000021408" version="SP_204" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000488" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007257" secondary="activation of JUN kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032757" secondary="positive regulation of interleukin-8 production" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070266" secondary="necroptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043410" secondary="positive regulation of MAPK cascade" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5689880" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071356" secondary="cellular response to tumor necrosis factor" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010942" secondary="positive regulation of cell death" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034612" secondary="response to tumor necrosis factor" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001245" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903265" secondary="positive regulation of tumor necrosis factor-mediated signaling pathway" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5357786" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5357956" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-75893" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5357905" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903800" secondary="positive regulation of production of miRNAs involved in gene silencing by miRNA" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001240" secondary="negative regulation of extrinsic apoptotic signaling pathway in absence of ligand" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" secondary="protein autophosphorylation" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-69416" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5675482" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005123" secondary="death receptor binding" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000129831" version="SP_204" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060546" secondary="negative regulation of necroptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046330" secondary="positive regulation of JNK cascade" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031264" secondary="death-inducing signaling complex" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5218900" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001238" secondary="positive regulation of extrinsic apoptotic signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-937041" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060545" secondary="positive regulation of necroptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043068" secondary="positive regulation of programmed cell death" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_204"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006516672.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5689896" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004706" secondary="JUN kinase kinase kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070231" secondary="T cell apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071363" secondary="cellular response to growth factor stimulus" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001237" secondary="negative regulation of extrinsic apoptotic signaling pathway" version="SP_204"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q60855" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000134" secondary="negative regulation of G1/S transition of mitotic cell cycle" version="SP_204"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006516670.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043235" secondary="receptor complex" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR025735" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042327" secondary="positive regulation of phosphorylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-3295583" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-140534" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000021844" version="SP_204" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045651" secondary="positive regulation of macrophage differentiation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097191" secondary="extrinsic apoptotic signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2562578" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8CD90" version="SP_78" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" secondary="positive regulation of protein phosphorylation" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097342" secondary="ripoptosome" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060044" secondary="negative regulation of cardiac muscle cell proliferation" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905206" secondary="positive regulation of hydrogen peroxide-induced cell death" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097343" secondary="ripoptosome assembly" version="SP_204"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS</sequence>
            </interactor>
            <interactor id="3263021">
                <names>
                    <shortLabel>fadd_mouse</shortLabel>
                    <fullName>FAS-associated death domain protein</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">FAS-associating death domain-containing protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Mediator of receptor induced toxicity</alias>
                    <alias typeAc="MI:0301" type="gene name">Fadd</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Mort1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q61160" version="SP_68" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045087" secondary="innate immune response" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001822" secondary="kidney development" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-140534" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000454" secondary="positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097192" secondary="extrinsic apoptotic signaling pathway in absence of ligand" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097202" secondary="activation of cysteine-type endopeptidase activity" version="SP_182"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000488" version="SP_182"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FAD" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045651" secondary="positive regulation of macrophage differentiation" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051607" secondary="defense response to virus" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-3371378" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048148" secondary="behavioral response to cocaine" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060546" secondary="negative regulation of necroptotic process" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071260" secondary="cellular response to mechanical stimulus" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008625" secondary="extrinsic apoptotic signaling pathway via death domain receptors" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060340" secondary="positive regulation of type I interferon-mediated signaling pathway" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035877" secondary="death effector domain binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070236" secondary="negative regulation of activation-induced cell death of T cells" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032757" secondary="positive regulation of interleukin-8 production" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043005" secondary="neuron projection" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097342" secondary="ripoptosome" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048738" secondary="cardiac muscle tissue development" version="SP_182"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016729" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002821" secondary="positive regulation of adaptive immune response" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2562578" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-75158" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045862" secondary="positive regulation of proteolysis" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097190" secondary="apoptotic signaling pathway" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043029" secondary="T cell homeostasis" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071550" secondary="death-inducing signaling complex assembly" version="SP_182"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001875" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032729" secondary="positive regulation of interferon-gamma production" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030217" secondary="T cell differentiation" version="SP_182"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034305.1"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-524415" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000033394" version="SP_182" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097191" secondary="extrinsic apoptotic signaling pathway" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-75157" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0089720" secondary="caspase binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_182"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000031077" version="SP_182" refType="gene"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5357786" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005164" secondary="tumor necrosis factor receptor binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_182"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3TC37" version="SP_68" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q61082" version="SP_68" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048536" secondary="spleen development" version="SP_182"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042104" secondary="positive regulation of activated T cell proliferation" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005123" secondary="death receptor binding" version="SP_182"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-34771N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001916" secondary="positive regulation of T cell mediated cytotoxicity" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033077" secondary="T cell differentiation in thymus" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097049" secondary="motor neuron apoptotic process" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031264" secondary="death-inducing signaling complex" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044297" secondary="cell body" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5218900" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001238" secondary="positive regulation of extrinsic apoptotic signaling pathway" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060544" secondary="regulation of necroptotic process" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032813" secondary="tumor necrosis factor receptor superfamily binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033612" secondary="receptor serine/threonine kinase binding" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031265" secondary="CD95 death-inducing signaling complex" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5357905" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-69416" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097527" secondary="necroptotic signaling pathway" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043278" secondary="response to morphine" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036462" secondary="TRAIL-activated apoptotic signaling pathway" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048538" secondary="thymus development" version="SP_182"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000033394" version="SP_182" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048535" secondary="lymph node development" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043123" secondary="positive regulation of I-kappaB kinase/NF-kappaB signaling" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032760" secondary="positive regulation of tumor necrosis factor production" version="SP_182"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002020" secondary="protease binding" version="SP_182"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5675482" version="SP_182"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q61160" version="SP_182"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-24119-1" id="3263022">
                <names>
                    <shortLabel>fadd-casp8-10</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-198645E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16093478" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24119-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3263016</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3263023">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093485" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263018</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3263024">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093484" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263019</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3263025">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093483" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263020</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3263026">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093482" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263021</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-24119-2" id="3263027">
                <names>
                    <shortLabel>fadd-casp8-11</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-198646E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24119-2" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16093497" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3263017</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3263028">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093503" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263018</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3263029">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093502" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263019</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3263030">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16093501" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3263021</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
