DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ lu-2014-12 human Homo sapiens Human pull down pull down anti tag western anti tag western blot anti tag western Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265015X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-13 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265020X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-14 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265013X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-15 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265022X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-16 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265023X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-17 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265018X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-18 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265014X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-19 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265017X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-20 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265021X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-21 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265024X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-22 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265016X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation lu-2014-23 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. DIP original experiment: DIP-265019X Science (New York, N.Y.) 2014 IMEx The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Lu G., Middleton RE., Sun H., Naniong M., Ott CJ., Mitsiades CS., Wong KK., Bradner JE., Kaelin WG. Only protein-protein interactions imex curation ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG q96sw2-2 Protein cereblon CRBN AD-006 protein protein human Homo sapiens Human MAGEGDQQDAAHNMGNHLPLLPESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL No experimental confirmation available. q13422-7 DNA-binding protein Ikaros IKZF1 IK1 IKAROS Ikaros family zinc finger protein 1 LYF1 Lymphoid transcription factor LyF-1 ZNFN1A1 protein protein human Homo sapiens Human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ikzf3_human Zinc finger protein Aiolos ZNFN1A3 Ikaros family zinc finger protein 3 IKZF3 protein protein human Homo sapiens Human MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK ddb1_human DNA damage-binding protein 1 DDB1 Damage-specific DNA-binding protein 1 UV-damaged DNA-binding factor DDB p127 subunit DNA damage-binding protein a UV-damaged DNA-binding protein 1 Xeroderma pigmentosum group E-complementing protein XPE-binding factor HBV X-associated protein 1 XAP1 protein protein human Homo sapiens Human MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH crbn_human Protein cereblon CRBN AD-006 protein protein human Homo sapiens Human MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL ikzf1_human DNA-binding protein Ikaros Ikaros family zinc finger protein 1 Lymphoid transcription factor LyF-1 IKZF1 IK1 IKAROS LYF1 ZNFN1A1 protein protein human Homo sapiens Human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS cul4a_human Cullin-4A CUL4A protein protein human Homo sapiens Human MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA q13422-1 DNA-binding protein Ikaros IKZF1 IK1 IKAROS LYF1 ZNFN1A1 Ikaros family zinc finger protein 1 Lymphoid transcription factor LyF-1 protein protein human Homo sapiens Human MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYEKENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLLLSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALRVVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS ub-crbn-1 3260543 N/A 3260555 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false human Homo sapiens Human N/A 3260556 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3260557 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human association association false false false crbn-ddb1-1 3260544 N/A 3260558 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3260559 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human association association false false false ikzf1-crbn-1 3260545 N/A 3260557 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3260560 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false crbn-ddb1-2 3260546 N/A 3260558 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260561 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260559 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human association association false false false ikzf3-crbn-1 3260547 N/A 3260558 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false Q9UKT9:p.Gln147His Q147H mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3260560 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false crbn-cul4a-1 3260548 N/A 3260562 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260559 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human association association false false false ikzf1-crbn-2 3260549 N/A 3260556 unspecified role unspecified role prey prey Q96SW2-2:p.[Tyr383Ala;Trp385Ala] Y383A/W385A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3260557 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human physical association physical association false false false crbn-cul4a-2 3260550 N/A 3260558 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3260562 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260559 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human association association false false false crbn-ddb1-3 3260551 N/A 3260559 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human physical association physical association false false false ikzf1-crbn-3 3260552 N/A 3260563 unspecified role unspecified role bait bait Q13422-1:p.Gln146His Q146H mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3260560 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false crbn-cul4a-3 3260553 N/A 3260562 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260559 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3260557 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human association association false false false crbn-ddb1-4 3260554 N/A 3260559 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3260556 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human physical association physical association false false false