DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ felix-2013-1 human Homo sapiens Human light scattering light scattering predetermined predetermined participant predetermined Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. DIP original experiment: DIP-252197X Structure (London, England : 1993) 2013 IMEx Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. Only protein-protein interactions imex curation felix-2013-2 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column weight by comassie molecular weight estimation by coomasie staining weight by comassie Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. DIP original experiment: DIP-252195X Structure (London, England : 1993) 2013 IMEx Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. Only protein-protein interactions imex curation felix-2013-3 human Homo sapiens Human tem transmission electron microscopy tem predetermined predetermined participant predetermined Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. DIP original experiment: DIP-252199X Structure (London, England : 1993) 2013 IMEx Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. Only protein-protein interactions imex curation felix-2013-4 human Homo sapiens Human saxs x ray scattering saxs predetermined predetermined participant predetermined Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. DIP original experiment: DIP-252198X Structure (London, England : 1993) 2013 IMEx Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. Only protein-protein interactions imex curation felix-2013-5 human Homo sapiens Human field flow fractionation field flow fractionation predetermined predetermined participant predetermined Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. DIP original experiment: DIP-252196X Structure (London, England : 1993) 2013 IMEx Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Felix J., Elegheert J., Gutsche I., Shkumatov AV., Wen Y., Bracke N., Pannecoucke E., Vandenberghe I., Devreese B., Svergun DI., Pauwels E., Vergauwen B., Savvides SN. Only protein-protein interactions imex curation csf1r_human Macrophage colony-stimulating factor 1 receptor CSF1R FMS Proto-oncogene c-Fms CSF-1 receptor protein protein human Homo sapiens Human MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC q6zmj4-1 Interleukin-34 IL34 C16orf77 protein protein human Homo sapiens Human MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP csf1r-il34-1 3251722 N/A 3251727 unspecified role unspecified role unspecified role unspecified role D1-D3 domain Region 20-290 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3251728 unspecified role unspecified role unspecified role unspecified role Region 21-200 Region 21-200 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false csf1r-il34-2 3251723 N/A 3251727 unspecified role unspecified role unspecified role unspecified role D1-D3 domain Region 20-290 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3251728 unspecified role unspecified role unspecified role unspecified role Region 21-200 Region 21-200 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false csf1r-il34-3 3251724 N/A 3251727 unspecified role unspecified role unspecified role unspecified role D1-D5 domain Region 20-502 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3251728 unspecified role unspecified role unspecified role unspecified role Region 21-242 Region 21-242 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false csf1r-il34-4 3251725 N/A 3251727 unspecified role unspecified role unspecified role unspecified role D1-D3 domain Region 20-290 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3251728 unspecified role unspecified role unspecified role unspecified role Region 21-200 Region 21-200 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false csf1r-il34-5 3251726 N/A 3251727 unspecified role unspecified role unspecified role unspecified role D1-D3 domain Region 20-290 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3251728 unspecified role unspecified role unspecified role unspecified role Region 21-200 Region 21-200 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false