DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ motz-2013-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266836X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-2 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266845X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-3 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266841X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-4 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266837X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-5 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266846X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-6 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266842X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-7 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266847X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-8 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266838X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-9 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266839X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-10 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266843X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-11 in vitro In vitro saxs x ray scattering saxs predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266848X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-12 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266840X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation motz-2013-13 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. DIP original experiment: DIP-266844X Science (New York, N.Y.) 2013 IMEx Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Motz C., Schuhmann KM., Kirchhofer A., Moldt M., Witte G., Conzelmann KK., Hopfner KP. Only protein-protein interactions imex curation a7lcx1_pig RNA helicase MDA5 protein protein pig Sus scrofa (Pig) Pig MSSDGYSADQNFCYLISCFRARVKRYIQVEPVLDYLTFLPAEVKEQIQRAVATTGNINAAELLLNTLEKGVWPPGWTRMFVQALRETGNSLAARYVNPDLTDLPSPSFESSHDECLQLLNLLQPTVVDKLLVTDVLDKCVEEQLLTGEDRNRVSAAENDGNESGVRELLKRIVQKENWFSTFLTVLRQTGNDALARELTGTDCCESNAESDDLLGENGPEVQEPLLLATDQPSLDVSDIEKSSLESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEETVAQRASPEPELHLRPYQLEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKEASEPGKVIVLVNKVPLVEQLFRKEFEPFLKKWYRVTRLSGDTQLKITFPEVVKSCDVIISTAQILENSLLNSEEGEDPGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLKNNKLKKEEKPVIPLPQILGLTASPGVGGAKKQAKAEEHILKICANLDAFTIKTVKKNINQLKDQIKEPCKKFVIADDTREDLFKDRLLEIMTNIQTFCQISPMSDFGTQPYEQWLIQMEKKAARDGNRKDRVCAEHLKKYNEALQINDTIRRIDAYNHLKTFYNDEKEKKFEVLEDDSDDNGDDSDNDEDENDEKKPSKLDESDIFLMTLFLRNKKILKKLAENPEYENEKLTKLRNTIMEHFTRTEESARGIIFTKTRQSAYALSQWITDNKKFAEVGVKAHHLIGAGHSSEFKPMTQNEQREVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAQSGSGVIERETVNDFREKMMYKAIDRVQNMKPEEYAHKILELQMQSIMEKKMKIKRSIAKQCKDNPSLISFLCKNCSVLACSGEDIHIIEKMHHVNMTPEFKNLYIVRGNKALQTKFADYQTNGEIICKKCGQAWGTMMVHKGLDLPCLKIKNYVVAFKNNLFKKQYKKWVELPITFPDLNYSEYCLSSDED v_piv5 Non-structural protein V P/V protein protein sv5 Simian virus 5 (strain W3) PIV5 Simian virus 5 MDPTDLSFSPDEINKLIETGLNTVEYFTSQQVTGTSSLGKNTIPPGVTGLLTNAAEAKIQESTNHQKGSVGGGAKPKKPRPKIAIVPADDKTVPGKPIPNPLLGLDSTPSTQTVLDLSGKTLPSGSYKGVKLAKFGKENLMTRFIEEPRENPIATSSPIDFKRGRDTGGFHRREYSIGWVGDEVKVTEWCNPSCSPITAAARRFECTCHQCPVTCSECERDT v_measc Non-structural protein V P/V protein protein measc measles virus (strai MAEEQARHVKNGLECIRALKAEPIGSLAVEEAMAAWSEISDNPGQDRATCKEEEAGSSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDAETLGIPSRNLQASSTGLQCYHVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDDESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLKLQSRGNNFPKLGKTLNVPPPPNPSRASTSETPIKKGHRREIGLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE ifih1_human Interferon-induced helicase C domain-containing protein 1 Helicase with 2 CARD domains Interferon-induced with helicase C domain protein 1 Melanoma differentiation-associated protein 5 Murabutide down-regulated protein RNA helicase-DEAD box protein 116 RIG-I-like receptor 2 IFIH1 MDA5 RH116 Clinically amyopathic dermatomyositis autoantigen 140 kDa protein protein human Homo sapiens Human MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVELLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNLLQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSAFLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGMENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARASPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFAIADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDEDDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCLFSDED d9n195_chick RNA helicase MDA5 protein protein chick Gallus gallus (Chicken) Chicken MSEECRDERFLYMISCFRPRLKRCIRVQPVLDWLPSLSAEEKDKVRAAALQRGEVEGAEELLCAVERGRRDPGWFTEFLLALKKGGCDLAACYVNPSQLPSPQEEDDHDLCVHLVQLLHGTLVDNMQTRQVAEKCLELGIFQEEDLVGIETVIESRGNRDGARELLSRIVQKKDWFSQFLVALRETQHESLADDLSGNTGGTEDKDYELKNNTGKKTEAASQPVYVTEDLKQQENLDDSFVRESSVLETSVGKNSVISESVAVGDASVSNSNENLGQSSTTSDSGEDEAEGRASPEPDLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKASEQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEVVKRYDVIICTAQILENSLLNATEEDESVRLSDFSLIIIDECHHTQKEGVYNNIMRRYLKEKIKNRKQAKENKPLIPQPQILGLTASPGVGGARSNSKAEEHILKICANLDACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQDIQKYCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYNDALQINDTIRMVDAYNHLNNFYKELKRRKTAESDDDEEPLVSKQDETDEFLMRLFHAKKKQLKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSALALYHWIMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGSINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVASSGSGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIVEKQMKAKRDQRKTYKKNPSLITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHKRENRTLQDKHADYQTNVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDKKTTKEIFKKWGELPIIFPDFDYASHCPSSDED q8r5f7-1 Interferon-induced helicase C domain-containing protein 1 Ifih1 Helicase with 2 CARD domains Interferon induced with helicase C domain protein 1 Melanoma differentiation-associated protein 5 RIG-I-like receptor 2 protein protein mouse Mus musculus Mouse MSIVCSAEDSFRNLILFFRPRLKMYIQVEPVLDHLIFLSAETKEQILKKINTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPTLTDLPSPSSETAHDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFLDVLRQTGNDALFQELTGGGCPEDNTDLANSSHRDGPAANECLLPAVDESSLETEAWNVDDILPEASCTDSSVTTESDTSLAEGSVSCFDESLGHNSNMGRDSGTMGSDSDESVIQTKRVSPEPELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDSDKSDDEASSCNDQLKGDVKKSLKLDETDEFLMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQKKFADYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCLYSDED h0z993_taegu RNA helicase IFIH1 protein protein taegu Taeniopygia guttata Zebra finch Poephila guttata MAEGTRDERFLYMISCFRPRLKQIIQAQPVLDQLPSLSAEDKDRVRAAALQRGAAAGAEELLRAVERGPRGCGWIREFLQALERGGCSLAACYANPSLSQLPSPAEEAEHDLCVHLVQLLHGTLVDRMRAVQVAEKCLQMGIFQDEDVDRIQTVTDNRGNRDGARELLSRIVQKKDWFSSFLIALRETQHEDLADDLSGNTGESKQNGMEQTTNEETEVTSQPGNVIEENLKQEENVDDSFSSESSLLETSIEKNSVVSESDVSIGDGGVSNSNENLEQSSTTSDSDEDEVERRASPEPDLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKKRASEPGKVIVLVNKVPLVEQHLKTEFSPFLKRWYQVIGLSGDSQLKISFPEVVRRNDVIISTAQILENSLLNASKEDEESVHLSDFSLIIIDECHHTQKEGVYNNIMRRYLKEKMKNRKLAKENKPLIPQPQILGLTASPGVGGATSYSKAEEHILKICANLDACRIMTVEEHASQLKNQVKEPSKKTVIADDKKRDPFKEKITEIMTEIQNYCQLHPKTEFGTQTYEQWVIREEKRAAKAEKRRERVCAEHLKKYNDALQINDTIRMVDAYNLLNNFYKEEKSKKTVRSDDDDDDKPAVSKQDETDEFLIGLFHAKKKQLKELTRKPENENEKLMKLRNTLMEEFTKTEEPRGIVFTKTRLSAFALFQWIKDNPKFEEVGIKAHYLIGSGHKSEMKPMTQNEQREVIDKFRCGNVNLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVVSSDSGAVERESVNIYREKMMYKAIQRVQKMPQEEYLNKIHNFQLQSIVEKQMKVMRDQRKTYKKNPSLIKFLCKNCSKSICSGEDIQVIEDMHHVSVKKDFQSLYHIRENKALQDKHADNQTNGEIICKDCGQAWGNMMVHRGLDLPCLKIRNFVVVFADKKTTNDIFKKWGDLPIRFPSFDYASHCPSSDED q6q899-1 Antiviral innate immune response receptor RIG-I Probable ATP-dependent RNA helicase DDX58 Ddx58 DEAD box protein 58 RIG-I-like receptor 1 Retinoic acid-inducible gene 1 protein Retinoic acid-inducible gene I protein protein protein mouse Mus musculus Mouse MTAEQRQNLQAFRDYIKKILDPTYILSYMSSWLEDEEVQYIQAEKNNKGPMEAASLFLQYLLKLQSEGWFQAFLDALYHAGYCGLCEAIESWDFQKIEKLEEHRLLLRRLEPEFKATVDPNDILSELSECLINQECEEIRQIRDTKGRMAGAEKMAECLIRSDKENWPKVLQLALEKDNSKFSELWIVDKGFKRAESKADEDDGAEASSIQIFIQEEPECQNLSQNPGPPSEASSNNLHSPLKPRNYQLELALPAKKGKNTIICAPTGCGKTFVSLLICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGYNIASISGATSDSVSVQHIIEDNDIIILTPQILVNNLNNGAIPSLSVFTLMIFDECHNTSKNHPYNQIMFRYLDHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAALDASVIATVRDNVAELEQVVYKPQKISRKVASRTSNTFKCIISQLMKETEKLAKDVSEELGKLFQIQNREFGTQKYEQWIVGVHKACSVFQMADKEEESRVCKALFLYTSHLRKYNDALIISEDAQMTDALNYLKAFFHDVREAAFDETERELTRRFEEKLEELEKVSRDPSNENPKLRDLYLVLQEEYHLKPETKTILFVKTRALVDALKKWIEENPALSFLKPGILTGRGRTNRATGMTLPAQKCVLEAFRASGDNNILIATSVADEGIDIAECNLVILYEYVGNVIKMIQTRGRGRARDSKCFLLTSSADVIEKEKANMIKEKIMNESILRLQTWDEMKFGKTVHRIQVNEKLLRDSQHKPQPVPDKENKKLLCGKCKNFACYTADIRVVETSHYTVLGDAFKERFVCKPHPKPKIYDNFEKKAKIFCAKQNCSHDWGIFVRYKTFEIPVIKIESFVVEDIVSGVQNRHSKWKDFHFERIQFDPAEMSV e1bjz0_bovin RNA helicase IFIH1 protein protein bovin Bos taurus (Bovine) Bovine MSSDGSSTDKNFCYLISCFRARVKRYIQVEPVLDYLTFLPPEVKEHIQRTAATTGDIQAADLLLNTLERGNWPLGWARMFVEALRQAGNPLAARYVNPELTDLPSPSSENAHDECLQLLNLLQPTLVDKLLVADVLDKCVEEKLLTIEDRNRVSAAENNGNEAGVRELLKRIVQKENWFSTFLTILRQTGNDALAREFTGTDCCEGSTESENLSQEDGLEVKEPLLLATDQPNLEVLDIENSSLESSFADSSIVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDDENVAQRASPEPELNLRPYQLEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKASEHGKVMVLVNKVPLVEQLFRKEFKPFLKKWYHVTRLSGDTQLKITFPEVVKSHDVIISTAQILENSLLNSEEGEDDGIELSDFSLIIIDECHHTNKEAVYNNIMRRFLKQKLKNNKLKKENKPVIPLPQIVGLTASPGVGGAKKQAKAEEHILKICANLDAVTIKTVKQNINLLKEQIKEPCKKFVIADDTKKDPFKDKLLEIMTKIQTFCQINPMSDFGTQPYEQWLIQMEKKAAKEGNRKDRVCAEHLRKYNEALQINDTIRMIDAYNHLETFYNDEKEKKFAVLLGDDSDESDDNGDDDVGDGKPPLKLHETDDFLISLFWGNKKKLKKLAQNPEHENEKLIKLRNTIMEQYSRTEGSARGIIFTKTRQSAYALSQWIIENEKFSEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAQSGSGVVERETVNDFREKMMYKAIDRVQNMKPEEYAHKILELQMQSIMEKKMKTKRSIAKQFKGKPSLINFLCKNCGVPACSGEDIHVIEKMHHVNMTPEFKKLYLVRGNKALQTMCVDYQTNGEIICNKCGQAWGTMMVHKGLDLPCLKIKNFVVVFQNNLPKKQYKKWVELPITFPDLNYSEYCLFSDED o95786-1 Antiviral innate immune response receptor RIG-I Probable ATP-dependent RNA helicase DDX58 DDX58 DEAD box protein 58 RIG-I-like receptor 1 Retinoic acid-inducible gene 1 protein Retinoic acid-inducible gene I protein protein protein human Homo sapiens Human MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAEMSK mda5-p/v-1 3249616 N/A 3249629 unspecified role unspecified role unspecified role unspecified role Region 546-808 Region 546-808 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role Region 168-219 Region 168-219 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-1 3249617 N/A 3249631 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3249632 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Q9BYX4:p.Arg806Leu R806L mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human physical association physical association false false false mda5-p/v-2 3249618 N/A 3249633 unspecified role unspecified role unspecified role unspecified role Region 297-864 Region 297-864 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false mda5-p/v-3 3249619 N/A 3249629 unspecified role unspecified role unspecified role unspecified role Region 303-887 Region 303-887 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-2 3249620 N/A 3249634 unspecified role unspecified role unspecified role unspecified role Region 305-890 Region 305-890 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role P11207:p.Glu174Ala E174A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-3 3249621 N/A 3249635 unspecified role unspecified role unspecified role unspecified role Region 363-935 Region 363-935 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ddx58-p/v-1 3249622 N/A 3249636 unspecified role unspecified role unspecified role unspecified role Q6Q899-1:p.[Leu715Arg;Glu717Gly] L715R/E717G mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-4 3249623 N/A 3249632 unspecified role unspecified role unspecified role unspecified role Region 304-890 Region 304-890 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-5 3249624 N/A 3249634 unspecified role unspecified role unspecified role unspecified role Region 305-890 Region 305-890 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q8R5F7-1:p.Arg806Leu R806L mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-6 3249625 N/A 3249631 unspecified role unspecified role prey prey P0C774:p.Glu235Ala E235A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3249632 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false ifih1-p/v-7 3249626 N/A 3249634 unspecified role unspecified role unspecified role unspecified role Region 305-890 Region 305-890 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ifih1-p/v-8 3249627 N/A 3249637 unspecified role unspecified role unspecified role unspecified role Region 303-885 Region 303-885 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3249630 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ddx58-p/v-2 3249628 N/A 3249631 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3249638 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false O95786-1:p.Leu714Arg L714R mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false O95786-1:p.[Leu714Arg;Glu716Gly] L714R/E716G mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human physical association physical association false false false