<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3247380">
                <names>
                    <shortLabel>kaylor-2013-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="23143414" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-266900X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nchembio.1114" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24841" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16023461" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9031">
                        <names>
                            <shortLabel>chick</shortLabel>
                            <fullName>Gallus gallus (Chicken)</fullName>
                            <alias typeAc="MI:1041" type="synonym">Chicken</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Kaylor JJ., Yuan Q., Cook J., Sarfare S., Makshanoff J., Miu A., Kim A., Kim P., Habib S., Roybal CN., Xu T., Nusinowitz S., Travis GH.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-266900X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature chemical biology</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2013</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Kaylor JJ.,  Yuan Q.,  Cook J.,  Sarfare S.,  Makshanoff J.,  Miu A.,  Kim A.,  Kim P.,  Habib S.,  Roybal CN.,  Xu T.,  Nusinowitz S.,  Travis GH.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3247381">
                <names>
                    <shortLabel>rlbp1_chick</shortLabel>
                    <fullName>Retinaldehyde-binding protein 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">RLBP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CRALBP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cellular retinaldehyde-binding protein</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="E1C1U1" version="22" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011074" version="SP_76"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_76"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALG00000006676" version="SP_76" refType="gene"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16023497" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-61752N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALP00000010782" version="SP_76" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019841" secondary="retinol binding" version="SP_76"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032941" version="SP_76"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036273" version="SP_76"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001251" version="SP_76"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-2453902" version="SP_76"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036865" version="SP_76"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001019865.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050896" secondary="response to stimulus" version="SP_76"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007601" secondary="visual perception" version="SP_76"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALT00000010796" version="SP_76" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016918" secondary="retinal binding" version="SP_76"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-2187335" version="SP_76"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9031">
                    <names>
                        <shortLabel>chick</shortLabel>
                        <fullName>Gallus gallus (Chicken)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Chicken</alias>
                    </names>
                </organism>
                <sequence>MSAVTGTFRIVSEEEQALRTKLERLTTKDHGPVFGRCQQIPPHTLQKAKDELNETEEQREAAVKALRELVQERAGSEDVCKAVAEKMQGKDDSFFLRFIRARKFDVHRAYDLLKGYVNFRQQYPELFDNLTPEAVRSTIEAGYPGILASRDKYGRVVMLFNIENWDYEEITFDEILRAYCVILEKLLENEETQINGFCIIENFKGFTMQQASGIKPSELKKMVDMLQDSFPARFKAVHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGEELESFYQEIDADILPADFGGNLPKYDGKATAEQLFGPRIEAEDTAL</sequence>
            </interactor>
            <interactor id="3247382">
                <names>
                    <shortLabel>degs1_chick</shortLabel>
                    <fullName>Sphingolipid delta(4)-desaturase DES1</fullName>
                    <alias typeAc="MI:0301" type="gene name">DEGS1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">DES1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Degenerative spermatocyte homolog 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Dihydroceramide desaturase-1</alias>
                    <alias typeAc="MI:0306" type="orf name">RCJMB04_22e12</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q5F3C1" version="59" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006633" secondary="fatty acid biosynthetic process" version="SP_97"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALP00000015178" version="SP_97" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001012583.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALG00000009330" version="SP_97" refType="gene"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-433584" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042284" secondary="sphingolipid delta-4 desaturase activity" version="SP_97"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-1660661" version="SP_97"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011388" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043217" secondary="myelin maintenance" version="SP_97"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005804" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005789" secondary="endoplasmic reticulum membrane" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050251" secondary="retinol isomerase activity" version="SP_97"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013866" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016859" secondary="cis-trans isomerase activity" version="SP_97"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSGALT00000015194" version="SP_97" refType="transcript"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16023472" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-61751N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_97"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-GGA-6798695" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_97"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046513" secondary="ceramide biosynthetic process" version="SP_97"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR031196" version="SP_97"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9031">
                    <names>
                        <shortLabel>chick</shortLabel>
                        <fullName>Gallus gallus (Chicken)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Chicken</alias>
                    </names>
                </organism>
                <sequence>MGNTVAREDFEWVYTDQPHADRRKEILAKHPEIKALMKPDYNLIWVVMLMVAAQLTAFYLVRDLDWKWVVFWAYVFGSCISHSMTLAIHEISHNSAFGNGRAMWNRWFGIFANLPLGLPYSISFKRYHMDHHRYLGGDGIDVDIPTNFEGWFFCTRFRKFIWIVLQPFFYAIRPLCINPKPITRLEIINLLAQLFFDIVIYYLWGAKSIFYMLAGSVLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVKKIAAEYYDNLPQYNSWIKVLYDFVMDDTISPYSRMKRQLKGEVKQD</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-24841-1" id="3247383">
                <names>
                    <shortLabel>degs1-rlbp1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-199832E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24841-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16023517" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3247380</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3247384">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16023522" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3247381</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9031">
                                <names>
                                    <shortLabel>chick</shortLabel>
                                    <fullName>Gallus gallus (Chicken)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Chicken</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3247385">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-16023521" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3247382</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9031">
                                <names>
                                    <shortLabel>chick</shortLabel>
                                    <fullName>Gallus gallus (Chicken)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Chicken</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
