DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ xu-2012-3 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Xu Z., Wei Z., Zhou JJ., Ye F., Lo WS., Wang F., Lau CF., Wu J., Nangle LA., Chiang KP., Yang XL., Zhang M., Schimmel P. DIP original experiment: DIP-250535X Structure (London, England : 1993) 2012 IMEx Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. Xu Z., Wei Z., Zhou JJ., Ye F., Lo WS., Wang F., Lau CF., Wu J., Nangle LA., Chiang KP., Yang XL., Zhang M., Schimmel P. Only protein-protein interactions imex curation xu-2012-4 ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Xu Z., Wei Z., Zhou JJ., Ye F., Lo WS., Wang F., Lau CF., Wu J., Nangle LA., Chiang KP., Yang XL., Zhang M., Schimmel P. DIP original experiment: DIP-250536X Structure (London, England : 1993) 2012 IMEx Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. Xu Z., Wei Z., Zhou JJ., Ye F., Lo WS., Wang F., Lau CF., Wu J., Nangle LA., Chiang KP., Yang XL., Zhang M., Schimmel P. Only protein-protein interactions imex curation hars1_human Histidine--tRNA ligase, cytoplasmic HARS1 HARS HRS Histidyl-tRNA synthetase protein protein human Homo sapiens Human MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC hars-1 3244886 N/A 3244888 unspecified role unspecified role unspecified role unspecified role Region 61-398 Region 61-398 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false Region 54-506 Region 54-506 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false hars-2 3244887 N/A 3244888 unspecified role unspecified role unspecified role unspecified role Region 54-506 Region 54-506 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false