DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ uniacke-2012-1 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250661X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-2 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250667X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-3 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250666X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-4 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250664X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-5 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250668X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-6 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250662X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-7 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250665X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation uniacke-2012-8 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. DIP original experiment: DIP-250663X Nature 2012 IMEx An oxygen-regulated switch in the protein synthesis machinery. Uniacke J., Holterman CE., Lachance G., Franovic A., Jacob MD., Fabian MR., Payette J., Holcik M., Pause A., Lee S. Only protein-protein interactions imex curation q9bwf3-1 RNA-binding protein 4 RBM4 RBM4A Lark homolog RNA-binding motif protein 4 RNA-binding motif protein 4a protein protein human Homo sapiens Human MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVEASKNKSKTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNAYGALDAYYKRCRAARSYEAVAAAAASVYNYAEQTLSQLPQVQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTAASTSYYGRDRSPLRRATAPVPTVGEGYGYGHESELSQASAAARNSLYDMARYEREQYADRARYSAF epas1_human Endothelial PAS domain-containing protein 1 EPAS1 HIF2A MOP2 Member of PAS protein 2 Basic-helix-loop-helix-PAS protein MOP2 BHLHE73 PASD2 Hypoxia-inducible factor 2-alpha HIF-1-alpha-like factor PAS domain-containing protein 2 Class E basic helix-loop-helix protein 73 protein protein human Homo sapiens Human MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPEHRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQDLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQAT if4e2_human Eukaryotic translation initiation factor 4E type 2 EIF4E2 mRNA cap-binding protein type 3 Eukaryotic translation initiation factor 4E-like 3 Eukaryotic translation initiation factor 4E homologous protein mRNA cap-binding protein 4EHP eIF4E-like protein 4E-LP EIF4EL3 protein protein human Homo sapiens Human MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKPRLNVP if4a1_human Eukaryotic initiation factor 4A-I EIF4A1 EIF4A DDX2A ATP-dependent RNA helicase eIF4A-1 protein protein human Homo sapiens Human MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI if4e_human Eukaryotic translation initiation factor 4E mRNA cap-binding protein eIF-4F 25 kDa subunit EIF4E EIF4EL1 EIF4F protein protein human Homo sapiens Human MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 4ebp1_human Eukaryotic translation initiation factor 4E-binding protein 1 Phosphorylated heat- and acid-stable protein regulated by insulin 1 EIF4EBP1 protein protein human Homo sapiens Human MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI epas1-rbm4-1 3241121 N/A 3241129 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241130 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false epas1-eif4e2-1 3241122 N/A 3241131 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241130 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false rbm4-eif4a1-2 3241123 N/A 3241132 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241131 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241129 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3241130 unspecified role unspecified role prey prey human Homo sapiens Human association association false false false epas1-rbm4-2 3241124 N/A 3241129 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241130 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N-terminal domain Region 2-290 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human physical association physical association false false false eif4ebp1-eif4e-4 3241125 N/A 3241133 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241134 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false epas1-rbm4-3 3241126 N/A 3241129 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241130 unspecified role unspecified role bait bait GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false epas1-eif4a1-1 3241127 N/A 3241132 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241131 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241129 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3241130 unspecified role unspecified role bait bait human Homo sapiens Human association association false false false rbm4-epas1-1 3241128 N/A 3241129 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3241130 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false