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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3235815">
                <names>
                    <shortLabel>miller-2012-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="22282804" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="3UKM" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25221" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-268297X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1126/science.1213274" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15965905" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="4922">
                        <names>
                            <shortLabel>picpa</shortLabel>
                            <fullName>Pichia pastoris (Yeast)</fullName>
                            <alias typeAc="MI:1041" type="synonym">Yeast</alias>
                            <alias typeAc="MI:1041" type="synonym">Pichia pastoris</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Miller AN., Long SB.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-268297X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Science (New York, N.Y.)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2012</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Crystal structure of the human two-pore domain potassium channel K2P1.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Miller AN.,  Long SB.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3235816">
                <names>
                    <shortLabel>kcnk1_human</shortLabel>
                    <fullName>Potassium channel subfamily K member 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">KCNK1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">HOHO1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">KCNO1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">TWIK1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Inward rectifying potassium channel protein TWIK-1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Potassium channel KCNO1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Potassium channel K2P1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="O00180" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060075" secondary="regulation of resting membrane potential" version="SP_187"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002236.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003092" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1299308" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030322" secondary="stabilization of membrane potential" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005272" secondary="sodium channel activity" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035725" secondary="sodium ion transmembrane transport" version="SP_187"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5T5E8" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000135750" version="SP_187" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030425" secondary="dendrite" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097060" secondary="synaptic membrane" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005242" secondary="inward rectifier potassium channel activity" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003280" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0022841" secondary="potassium ion leak channel activity" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013099" version="SP_187"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-3914675" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043204" secondary="perikaryon" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034705" secondary="potassium channel complex" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3UKM" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005267" secondary="potassium channel activity" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" secondary="intracellular membrane-bounded organelle" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5576886" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055037" secondary="recycling endosome" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001779" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902937" secondary="inward rectifier potassium channel complex" version="SP_187"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008076" secondary="voltage-gated potassium channel complex" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031526" secondary="brush border membrane" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005408" version="SP_187"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000366621" version="SP_187" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006813" secondary="potassium ion transport" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" secondary="apical plasma membrane" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071805" secondary="potassium ion transmembrane transport" version="SP_187"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q13307" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035094" secondary="response to nicotine" version="SP_187"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-59532N"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPANH</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-25221-1" id="3235817">
                <names>
                    <shortLabel>kcnk1-4</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-188396E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15965917" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25221-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3235815</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3235818">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15965921" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3235816</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3235819">
                                <names>
                                    <shortLabel>Region 19-288</shortLabel>
                                    <fullName>Region 19-288</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15965922" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
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                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
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                                            </xref>
                                        </startStatus>
                                        <begin position="19"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
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                                            </xref>
                                        </endStatus>
                                        <end position="288"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="4922">
                                <names>
                                    <shortLabel>picpa</shortLabel>
                                    <fullName>Pichia pastoris (Yeast)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Yeast</alias>
                                    <alias typeAc="MI:1041" type="synonym">Pichia pastoris</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
