DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ wang-2011-19 ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Wang J., Wu JW., Wang ZX. DIP original experiment: DIP-220144X Structure (London, England : 1993) 2011 IMEx Structural insights into the autoactivation mechanism of p21-activated protein kinase. Wang J., Wu JW., Wang ZX. Only protein-protein interactions imex curation wang-2011-20 in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Wang J., Wu JW., Wang ZX. DIP original experiment: DIP-220145X Structure (London, England : 1993) 2011 IMEx Structural insights into the autoactivation mechanism of p21-activated protein kinase. Wang J., Wu JW., Wang ZX. Only protein-protein interactions imex curation wang-2011-21 in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Wang J., Wu JW., Wang ZX. DIP original experiment: DIP-220146X Structure (London, England : 1993) 2011 IMEx Structural insights into the autoactivation mechanism of p21-activated protein kinase. Wang J., Wu JW., Wang ZX. Only protein-protein interactions imex curation q13153-1 Serine/threonine-protein kinase PAK 1 PAK1 Alpha-PAK p21-activated kinase 1 p65-PAK protein protein human Homo sapiens Human MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH paktide Pak1 substrate peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) TPEQSKRSTMVGTPY pak1_rat Serine/threonine-protein kinase PAK 1 p21-activated kinase 1 p68-PAK Alpha-PAK Protein kinase MUK2 Pak1 protein protein rat Rattus norvegicus (Rat) Rat MSNNGLDVQDKPPAPPMRNTSTMIGAGSKDPGTLNHGSKPLPPNPEEKKKKDRFYRSILAGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDEDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH pak1-6 3233572 N/A 3233575 unspecified role unspecified role unspecified role unspecified role Kinase domain Region 249-545 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q13153-1:p.Asp389Asn D389N mutation increasing mutation increasing interaction mutation increasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false pak1-paktide-1 3233573 N/A 3233576 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro N/A 3233575 enzyme enzyme unspecified role unspecified role Kinase domain Region 249-545 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli phosphorylation phosphorylation reaction phosphorylation false false false pak1-paktide-2 3233574 N/A 3233577 enzyme enzyme unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm N/A 3233576 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro phosphorylation phosphorylation reaction phosphorylation false false false