DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ zhang-2011-11 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253862X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-12 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253855X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-13 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253858X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-14 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253860X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-15 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253865X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-16 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253864X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-17 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253856X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-18 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253859X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-19 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253863X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-20 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253861X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation zhang-2011-21 rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. DIP original experiment: DIP-253857X Proceedings of the National Academy of Sciences of the United States of America 2011 IMEx C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG., Han D., Wang RM., Dong Y., Yang F., Vadlamudi RK., Brann DW. Only protein-protein interactions imex curation esr1_rat Estrogen receptor Esr1 Esr Estr Nr3a1 Estradiol receptor ER-alpha Nuclear receptor subfamily 3 group A member 1 protein protein rat Rattus norvegicus (Rat) Rat MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPHVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI mint Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues f10a1_rat Hsc70-interacting protein Protein ST13 homolog Protein FAM10A1 St13 Fam10a1 Hip protein protein rat Rattus norvegicus (Rat) Rat MDPRKVSELRAFVKMCRQDPSVLHTEEMRFLREWVESMGGKVPPATHKAKSEENTKEEKRDKTTEDNIKTEEPSSEESDLEIDNEGVIEADTDAPQEMGDENAEITEAMMDEANEKKGAAIDALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAARDLALACKLDYDEDASAMLREVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHEKAQREEEARRQSGSQFGSFPGGFPGGMPGNFPGGMPGMGGAMPGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPSNMSKYQNNPKVMNLISKLSAKFGGHS ubiq_rat Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb protein protein rat Rattus norvegicus (Rat) Rat MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair mint bag1_rat BAG family molecular chaperone regulator 1 Bag1 Bcl-2-associated athanogene 1 protein protein rat Rattus norvegicus (Rat) Rat MADRGGARRPRGDQEPLGPRLRAPRSARETRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAASGACKPRVKKKVRPRSSQSEKVAHSKELTRSKKLTRSKKVTGTQEATQVEEVTTIEEATQTEEITVAEEVTQTENMAQTEEMVQTEEMEPPTLSVVVTHSNERYDLLVTPQQGNSEPIVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEAELKKLKDLEVSVEKTANHLEELNKELSDIQQGFLAKELQAEALCRLDRKIKATIEQFMKILEEIDTMVLPENFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALPE nedd8_rat NEDD8 Nedd8 Neddylin Ubiquitin-like protein NEDD8 protein protein rat Rattus norvegicus (Rat) Rat MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ esr2_rat Estrogen receptor beta Esr2 Erbeta Nr3a2 Nuclear receptor subfamily 3 group A member 2 protein protein rat Rattus norvegicus (Rat) Rat MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ esr1-st13-1 3228975 N/A 3228986 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228987 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association false false false esr1-ub-3 3228976 N/A 3228988 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228986 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association false false false ub-esr1-1 3228977 N/A 3228988 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228986 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association false false false st13-bag1-2 3228978 N/A 3228986 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228989 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228987 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat association association false false false esr1-nedd8-1 3228979 N/A 3228986 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228990 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association false false false esr2-ub-1 3228980 N/A 3228988 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228991 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association false false false ub-esr1-2 3228981 N/A 3228988 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228986 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association false false false esr1-bag1-1 3228982 N/A 3228986 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228989 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228987 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association false false false esr2-st13-1 3228983 N/A 3228988 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228991 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228987 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association false false false esr1-bag1-2 3228984 N/A 3228988 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228986 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat N/A 3228989 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228987 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association false false false esr1-ub-4 3228985 N/A 3228988 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat N/A 3228986 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association false false false