DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ shi-2011-7 crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219030X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-8 crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219031X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-9 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219038X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-10 human Homo sapiens Human light scattering light scattering predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219034X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-11 crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219036X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-12 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219032X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-13 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219033X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-14 in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219039X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-15 human Homo sapiens Human tem transmission electron microscopy tem predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219040X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-16 human Homo sapiens Human tem transmission electron microscopy tem predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219035X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation shi-2011-17 human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219037X Nature 2011 IMEx Latent TGF-β structure and activation. Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions imex curation tgfb1_pig Transforming growth factor beta-1 proprotein TGFB1 protein protein pig Sus scrofa (Pig) Pig MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGDVPPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKGTPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNDSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS itb6_human Integrin beta-6 ITGB6 protein protein human Homo sapiens Human MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC itav_human Integrin alpha-V ITGAV VNRA Vitronectin receptor subunit alpha MSK8 Vitronectin receptor VTNR protein protein human Homo sapiens Human MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET tgfb1_human Transforming growth factor beta-1 proprotein TGFB1 TGFB protein protein human Homo sapiens Human MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS q14766-1 Latent-transforming growth factor beta-binding protein 1 LTBP1 Transforming growth factor beta-1-binding protein 1 LTBP-1L protein protein human Homo sapiens Human MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIHHGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE tgfb1-tgfb1-1 3227553 N/A 3227564 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3227564 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction false false false itgav-itgb6-1 3227554 N/A 3227565 unspecified role unspecified role unspecified role unspecified role Ectodomain region 22-709 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3227566 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 31-992 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction false false false tgfb1-tgfb1-2 3227555 N/A 3227567 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false ltbp1-tgfb1-1 3227556 N/A 3227568 unspecified role unspecified role unspecified role unspecified role Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction false false false tgfb1-tgfb1-3 3227557 N/A 3227564 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3227564 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction false false false ltbp1-tgfb1-2 3227558 N/A 3227568 unspecified role unspecified role unspecified role unspecified role Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction false false false itgav-itgb6-2 3227559 N/A 3227567 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227565 unspecified role unspecified role unspecified role unspecified role Ectodomain region 22-709 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3227566 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 31-992 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association false false false itgav-itgb6-3 3227560 N/A 3227567 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227565 unspecified role unspecified role unspecified role unspecified role Ectodomain region 22-709 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3227566 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 31-992 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association false false false tgfb1-tgfb1-4 3227561 N/A 3227567 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false ltbp1-tgfb1-3 3227562 N/A 3227568 unspecified role unspecified role unspecified role unspecified role Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3227567 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction false false false ltbp1-tgfb1-4 3227563 N/A 3227568 unspecified role unspecified role bait bait Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false SBP-tag SBP-tag sbp sbp undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human Homo sapiens Human N/A 3227567 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false