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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
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            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3223803">
                <names>
                    <shortLabel>smirnovas-2011-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="21441913" refType="primary-reference" refTypeAc="MI:0358"/>
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                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-218524X" refType="identity" refTypeAc="MI:0356"/>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10090">
                        <names>
                            <shortLabel>mouse</shortLabel>
                            <fullName>Mus musculus</fullName>
                            <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>tem</shortLabel>
                        <fullName>transmission electron microscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">tem</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Smirnovas V., Baron GS., Offerdahl DK., Raymond GJ., Caughey B., Surewicz WK.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-218524X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature structural &amp; molecular biology</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2011</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Smirnovas V.,  Baron GS.,  Offerdahl DK.,  Raymond GJ.,  Caughey B.,  Surewicz WK.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="3223804">
                <names>
                    <shortLabel>smirnovas-2011-2</shortLabel>
                </names>
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                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="21441913" refType="primary-reference" refTypeAc="MI:0358"/>
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                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-218525X" refType="identity" refTypeAc="MI:0356"/>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>atomic force microsc</shortLabel>
                        <fullName>atomic force microscopy</fullName>
                        <alias typeAc="MI:0303" type="go synonym">AFM</alias>
                        <alias typeAc="MI:1041" type="synonym">AFM</alias>
                        <alias typeAc="MI:1041" type="synonym">atomic force microsc</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0872" refType="identity" refTypeAc="MI:0356"/>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Smirnovas V., Baron GS., Offerdahl DK., Raymond GJ., Caughey B., Surewicz WK.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-218525X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature structural &amp; molecular biology</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2011</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Smirnovas V.,  Baron GS.,  Offerdahl DK.,  Raymond GJ.,  Caughey B.,  Surewicz WK.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3223805">
                <names>
                    <shortLabel>prio_mouse</shortLabel>
                    <fullName>Major prion protein</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">PrP27-30</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PrP33-35C</alias>
                    <alias typeAc="MI:0301" type="gene name">Prnp</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Prn-p</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Prp</alias>
                </names>
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                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P04925" version="SP_90" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2L1E" version="SP_221"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032703" secondary="negative regulation of interleukin-2 production" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005509" secondary="calcium ion binding" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000817" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904646" secondary="cellular response to amyloid-beta" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032689" secondary="negative regulation of interferon-gamma production" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR025860" version="SP_221"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000091288" version="SP_221" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_221"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2KU6" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031802" secondary="type 5 metabotropic glutamate receptor binding" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901216" secondary="positive regulation of neuron death" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006139" secondary="nucleobase-containing compound metabolic process" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090647" secondary="modulation of age-related behavioral decline" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903135" secondary="cupric ion binding" version="SP_221"/>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-16096-1" id="3223806">
                <names>
                    <shortLabel>prnp-29</shortLabel>
                </names>
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                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-144096E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16096-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15917037" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3223803</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3223807">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15917041" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3223805</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-16096-2" id="3223808">
                <names>
                    <shortLabel>prnp-30</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-144096E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16096-2" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15917053" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3223804</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3223809">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15917057" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3223805</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3223810">
                                <names>
                                    <shortLabel>Region 89-231</shortLabel>
                                    <fullName>Region 89-231</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15917058" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="89"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="231"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
