DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ truebestein-2011-1 ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Truebestein L., Tennstaedt A., Mönig T., Krojer T., Canellas F., Kaiser M., Clausen T., Ehrmann M. DIP original experiment: DIP-218467X Nature structural & molecular biology 2011 IMEx Substrate-induced remodeling of the active site regulates human HTRA1 activity. Truebestein L., Tennstaedt A., Mönig T., Krojer T., Canellas F., Kaiser M., Clausen T., Ehrmann M. Only protein-protein interactions imex curation truebestein-2011-2 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Truebestein L., Tennstaedt A., Mönig T., Krojer T., Canellas F., Kaiser M., Clausen T., Ehrmann M. DIP original experiment: DIP-218468X Nature structural & molecular biology 2011 IMEx Substrate-induced remodeling of the active site regulates human HTRA1 activity. Truebestein L., Tennstaedt A., Mönig T., Krojer T., Canellas F., Kaiser M., Clausen T., Ehrmann M. Only protein-protein interactions imex curation htra1_human Serine protease HTRA1 HTRA1 HTRA PRSS11 High-temperature requirement A serine peptidase 1 L56 Serine protease 11 protein protein human Homo sapiens Human MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP htra1-1 3222266 N/A 3222268 unspecified role unspecified role unspecified role unspecified role Protease domain Region 158-373 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false htra1-2 3222267 N/A 3222268 unspecified role unspecified role unspecified role unspecified role Protease domain Region 158-373 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false