DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ law-2010-1 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Law RH., Lukoyanova N., Voskoboinik I., Caradoc-Davies TT., Baran K., Dunstone MA., D'Angelo ME., Orlova EV., Coulibaly F., Verschoor S., Browne KA., Ciccone A., Kuiper MJ., Bird PI., Trapani JA., Saibil HR., Whisstock JC. DIP original experiment: DIP-219278X Nature 2010 IMEx The structural basis for membrane binding and pore formation by lymphocyte perforin. Law RH., Lukoyanova N., Voskoboinik I., Caradoc-Davies TT., Baran K., Dunstone MA., D'Angelo ME., Orlova EV., Coulibaly F., Verschoor S., Browne KA., Ciccone A., Kuiper MJ., Bird PI., Trapani JA., Saibil HR., Whisstock JC. Only protein-protein interactions imex curation law-2010-2 in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Law RH., Lukoyanova N., Voskoboinik I., Caradoc-Davies TT., Baran K., Dunstone MA., D'Angelo ME., Orlova EV., Coulibaly F., Verschoor S., Browne KA., Ciccone A., Kuiper MJ., Bird PI., Trapani JA., Saibil HR., Whisstock JC. DIP original experiment: DIP-219279X Nature 2010 IMEx The structural basis for membrane binding and pore formation by lymphocyte perforin. Law RH., Lukoyanova N., Voskoboinik I., Caradoc-Davies TT., Baran K., Dunstone MA., D'Angelo ME., Orlova EV., Coulibaly F., Verschoor S., Browne KA., Ciccone A., Kuiper MJ., Bird PI., Trapani JA., Saibil HR., Whisstock JC. Only protein-protein interactions imex curation law-2010-3 in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Law RH., Lukoyanova N., Voskoboinik I., Caradoc-Davies TT., Baran K., Dunstone MA., D'Angelo ME., Orlova EV., Coulibaly F., Verschoor S., Browne KA., Ciccone A., Kuiper MJ., Bird PI., Trapani JA., Saibil HR., Whisstock JC. DIP original experiment: DIP-219280X Nature 2010 IMEx The structural basis for membrane binding and pore formation by lymphocyte perforin. Law RH., Lukoyanova N., Voskoboinik I., Caradoc-Davies TT., Baran K., Dunstone MA., D'Angelo ME., Orlova EV., Coulibaly F., Verschoor S., Browne KA., Ciccone A., Kuiper MJ., Bird PI., Trapani JA., Saibil HR., Whisstock JC. Only protein-protein interactions imex curation perf_human Perforin-1 Lymphocyte pore-forming protein Cytolysin PRF1 PFP protein protein human Homo sapiens Human MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW perf_mouse Perforin-1 Prf1 Pfp Lymphocyte pore-forming protein Cytolysin protein protein mouse Mus musculus Mouse MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPVNTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREAAANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGGRISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYKACEEKKKQHKMATSFHQTYRERHVEVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSRARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAHLVVSNFRAEHLWGDYTTATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQVWDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGGTCLEYAPQGLLGDPPGNRSGAVW mint In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing non-specifically a variety of target cells prf1-1 3216850 N/A 3216853 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction false false false prf1-2 3216851 N/A 3216853 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction false false false prf1-3 3216852 N/A 3216854 unspecified role unspecified role unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction false false false