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        <source releaseDate="2017-08-31+01:00">
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                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
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                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
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                    <shortLabel>zhou-2010-25</shortLabel>
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                        <shortLabel>protease assay</shortLabel>
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                    <names>
                        <shortLabel>predetermined</shortLabel>
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                    <attribute name="author-list" nameAc="MI:0636">Zhou A., Carrell RW., Murphy MP., Wei Z., Yan Y., Stanley PL., Stein PE., Broughton Pipkin F., Read RJ.</attribute>
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                    <attribute name="publication year" nameAc="MI:0886">2010</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">A redox switch in angiotensinogen modulates angiotensin release.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Zhou A.,  Carrell RW.,  Murphy MP.,  Wei Z.,  Yan Y.,  Stanley PL.,  Stein PE.,  Broughton Pipkin F.,  Read RJ.</attribute>
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                <names>
                    <shortLabel>zhou-2010-26</shortLabel>
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                            <shortLabel>in vitro</shortLabel>
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                    <shortLabel>angt_human</shortLabel>
                    <fullName>Angiotensinogen</fullName>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1989781" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034374" secondary="low-density lipoprotein particle remodeling" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001974" secondary="blood vessel remodeling" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010873" secondary="positive regulation of cholesterol esterification" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045742" secondary="positive regulation of epidermal growth factor receptor signaling pathway" version="SP_240"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M3Y" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005179" secondary="hormone activity" version="SP_240"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000135744" version="SP_240" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5E2Q" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007267" secondary="cell-cell signaling" version="SP_240"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-751728" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035813" secondary="regulation of renal sodium excretion" version="SP_240"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CK0" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043407" secondary="negative regulation of MAP kinase activity" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007202" secondary="activation of phospholipase C activity" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048018" secondary="receptor ligand activity" version="SP_240"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051387" secondary="negative regulation of neurotrophin TRK receptor signaling pathway" version="SP_240"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023795" version="SP_240"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA</sequence>
            </interactor>
            <interactor id="3215540">
                <names>
                    <shortLabel>reni_human</shortLabel>
                    <fullName>Renin</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Angiotensinogenase</alias>
                    <alias typeAc="MI:0301" type="gene name">REN</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P00797" version="SP_104" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5T4S" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OWN" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G27" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001969" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4XX3" version="SP_234"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000528.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HRN" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJ7" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3SFC" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035690" secondary="cellular response to drug" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035902" secondary="response to immobilization stress" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2V16" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4RYC" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021109" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051591" secondary="response to cAMP" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VSW" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2IKU" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3Q5H" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OQK" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJ5" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BIM" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3GW5" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033121" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043408" secondary="regulation of MAPK cascade" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G1R" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OAG" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4RYG" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VYF" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008233" secondary="peptidase activity" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2V0Z" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4PYV" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G22" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5V8V" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VUC" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2V12" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RNE" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4RZ1" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006508" secondary="proteolysis" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2IKO" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VCM" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032496" secondary="response to lipopolysaccharide" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3K1W" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G1O" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G20" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2X0B" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VYD" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3Q4B" version="SP_234"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2022377" version="SP_234"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000272190" version="SP_234" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VRP" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2BKS" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3O9L" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJC" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5SY2" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2V10" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6I3F" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045177" secondary="apical part of cell" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2IL2" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5TMG" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJ6" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6T5C2" version="SP_104" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KOS" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3Q3T" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001823" secondary="mesonephros development" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4S1G" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002003" secondary="angiotensin maturation" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2FS4" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3G70" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4XX4" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BBS" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G26" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJA" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4AMT" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OAD" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJ8" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048469" secondary="cell maturation" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009755" secondary="hormone-mediated signaling pathway" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2REN" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2V13" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VPM" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G1Y" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001461" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OOT" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KOQ" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008217" secondary="regulation of blood pressure" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3D91" version="SP_234"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000143839" version="SP_234" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008584" secondary="male gonad development" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_234"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-59219N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000272190" version="SP_234" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G1S" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G24" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070305" secondary="response to cGMP" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5TMK" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VSX" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050435" secondary="amyloid-beta metabolic process" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5SZ9" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BIL" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005159" secondary="insulin-like growth factor receptor binding" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2I4Q" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2V11" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G21" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5SXN" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJD" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VYE" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001822" secondary="kidney development" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5SY3" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3G6Z" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJB" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004190" secondary="aspartic-type endopeptidase activity" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002018" secondary="renin-angiotensin regulation of aldosterone production" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2BKT" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3G72" version="SP_234"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6FI38" version="SP_131" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GJ9" version="SP_234"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012848" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OQF" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G1N" version="SP_234"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042756" secondary="drinking behavior" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KOT" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4Q1N" version="SP_234"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-715794" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034135" version="SP_234"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3KM4" version="SP_234"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-16271-1" id="3215541">
                <names>
                    <shortLabel>agt-ren-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-187386E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15882764" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16271-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3215537</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3215542">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15882769" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3215539</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>enzyme target</shortLabel>
                                <fullName>enzyme target</fullName>
                                <alias typeAc="MI:0303" type="go synonym">substrate</alias>
                                <alias typeAc="MI:1041" type="synonym">substrate</alias>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-64" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3215543">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15882768" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3215540</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>enzyme</shortLabel>
                                <fullName>enzyme</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-46" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>protein cleavage</shortLabel>
                        <fullName>protein cleavage</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0570" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14744292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-705088" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-16271-2" id="3215544">
                <names>
                    <shortLabel>agt-ren-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-187386E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15882782" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16271-2" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3215538</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3215545">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15882787" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3215539</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3215546">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15882786" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3215540</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
