DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ janssen-2010-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219283X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-2 human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219297X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-3 human Homo sapiens Human light scattering light scattering predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219288X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-4 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219284X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-5 human Homo sapiens Human light scattering light scattering predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219289X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-6 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219293X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-7 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219285X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-8 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219290X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-9 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219291X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-10 human Homo sapiens Human solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219294X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-11 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219296X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-12 human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219286X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-13 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219292X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-14 human Homo sapiens Human light scattering light scattering predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219295X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation janssen-2010-15 human Homo sapiens Human solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. DIP original experiment: DIP-219287X Nature 2010 IMEx Structural basis of semaphorin-plexin signalling. Janssen BJ., Robinson RA., Pérez-Brangulí F., Bell CH., Mitchell KJ., Siebold C., Jones EY. Only protein-protein interactions imex curation q92854-1 Semaphorin-4D SEMA4D C9orf164 CD100 SEMAJ A8 BB18 GR3 protein protein human Homo sapiens Human MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD o43157-1 Plexin-B1 PLXNB1 KIAA0407 PLXN5 SEP Semaphorin receptor SEP protein protein human Homo sapiens Human MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADPTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL o35464-1 Semaphorin-6A Sema6a Semaq Semaphorin Q Semaphorin VIA Semaphorin-6A-1 protein protein mouse Mus musculus Mouse MRPAALLLCLTLLHCAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNRTLYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIILKFLARIGSSGFLNGSLFLEEMNVYNPEKCSYDGVEDKRIMGMQLDRASGSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVRESGSCAHLSPLSRLTFEQDIERGNTDGLGDCHNSFVALNGHASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRESYLKSNDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPNRGSREWERNQNIINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGTSLSQTGLSKRLEMQHSSSYGLEYKRSYPTNSLTRSHQTTTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT plxa2_mouse Plexin-A2 Plxna2 Kiaa0463 protein protein mouse Mus musculus Mouse MEQRRFYLRAMQADNLSVVLLSVAWLLLARGTTGMPQYSTFHSENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEANRFAASISQCMSLEVHPNSISVSDHSRLLSLVVNDAPNLSEGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINVSEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCTLHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQIVCEMGHAVIGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMNEIVCVSPPSSNGLGPVPVSVSVDRARVDSSLQFEYIDDPRVQRIEPEWSITSGHTPLTITGFNLDVIQEPRVRVKFNGKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPDEFGFLFNNVQSLLIYNDTKFIYYPNPTFELLSPTGILDQKPGSPIILKGKNLCPPASGGAKLNYTVMIGETPCTVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHATEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEHLINAMSIES plxnb1-sema4d-1 3215119 N/A 3215134 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 22-677 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3215135 unspecified role unspecified role unspecified role unspecified role Region 20-535 Region 20-535 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema6a-1 3215120 N/A 3215136 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema4d-1 3215121 N/A 3215134 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 22-677 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q92854-1:p.[Phe244Asn;Phe246Ser] F244N/F246S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false plxnb1-sema4d-2 3215122 N/A 3215134 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 22-677 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster N/A 3215135 unspecified role unspecified role unspecified role unspecified role Region 20-535 Region 20-535 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema6a-2 3215123 N/A 3215136 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false plxna2-sema6a-1 3215124 N/A 3215137 unspecified role unspecified role bait bait Region 35-703 Region 35-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false P70207:p.Phe221Arg F221R mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false P70207:p.Ala396Glu A396E mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3215136 unspecified role unspecified role prey prey Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false plxna2-sema6a-2 3215125 N/A 3215137 unspecified role unspecified role unspecified role unspecified role Region 35-703 Region 35-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3215136 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema6a-3 3215126 N/A 3215136 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false plxnb1-sema4d-3 3215127 N/A 3215134 unspecified role unspecified role prey prey Ectodomain Region 22-677 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q92854-1:p.[Phe181Glu;Leu182Arg] F181E/L182R mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false Q92854-1:p.[Lys100Asp;Gly101Thr] K100D/G101T mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3215135 unspecified role unspecified role bait bait Region 20-535 Region 20-535 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema4d-2 3215128 N/A 3215134 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 22-677 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q92854-1:p.[Phe244Asn;Phe246Ser] F244N/F246S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false plxna2-1 3215129 N/A 3215137 unspecified role unspecified role unspecified role unspecified role Region 35-1040 Region 35-1040 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema4d-3 3215130 N/A 3215134 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 22-677 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q92854-1:p.[Phe244Asn;Phe246Ser] F244N/F246S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema6a-plxna2-1 3215131 N/A 3215137 unspecified role unspecified role prey prey Region 35-703 Region 35-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3215136 unspecified role unspecified role bait bait Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false O35464-1:p.Leu191Arg L191R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false plxna2-2 3215132 N/A 3215137 unspecified role unspecified role unspecified role unspecified role Region 35-1231 Region 35-1231 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false sema6a-4 3215133 N/A 3215136 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 19-571 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false O35464-1:p.Ile322Glu I322E mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human direct interaction direct interaction false false false