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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
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            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3208867">
                <names>
                    <shortLabel>chen-2010-20</shortLabel>
                </names>
                <bibref>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human</shortLabel>
                            <fullName>Homo sapiens</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
                        </names>
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                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Chen Z., Peng IC., Cui X., Li YS., Chien S., Shyy JY.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-219792X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2010</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Shear stress, SIRT1, and vascular homeostasis.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Chen Z.,  Peng IC.,  Cui X.,  Li YS.,  Chien S.,  Shyy JY.</attribute>
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                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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            </experimentDescription>
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                    <shortLabel>nos3_human</shortLabel>
                    <fullName>Nitric oxide synthase, endothelial</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">EC-NOS</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">NOS type III</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Constitutive NOS</alias>
                    <alias typeAc="MI:0301" type="gene name">NOS3</alias>
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                    </names>
                </organism>
                <sequence>MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP</sequence>
            </interactor>
            <interactor id="3208869">
                <names>
                    <shortLabel>sir1_human</shortLabel>
                    <fullName>NAD-dependent protein deacetylase sirtuin-1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">NAD-dependent protein deacylase sirtuin-1</alias>
                    <alias typeAc="MI:0301" type="gene name">SIRT1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SIR2L1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SIR2-like protein 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Regulatory protein SIR2 homolog 1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q96EB6" version="SP_67" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007283" secondary="spermatogenesis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000978" secondary="RNA polymerase II cis-regulatory region sequence-specific DNA binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043161" secondary="proteasome-mediated ubiquitin-dependent protein catabolic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051152" secondary="positive regulation of smooth muscle cell differentiation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090335" secondary="regulation of brown fat cell differentiation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032007" secondary="negative regulation of TOR signaling" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000183" secondary="rDNA heterochromatin assembly" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000096717" version="SP_204" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ZZI" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070301" secondary="cellular response to hydrogen peroxide" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010883" secondary="regulation of lipid storage" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034983" secondary="peptidyl-lysine deacetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043433" secondary="negative regulation of DNA-binding transcription factor activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031648" secondary="protein destabilization" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000480" secondary="negative regulation of cAMP-dependent protein kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900113" secondary="negative regulation of histone H3-K9 trimethylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004407" secondary="histone deacetylase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035356" secondary="cellular triglyceride homeostasis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032088" secondary="negative regulation of NF-kappaB transcription factor activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033210" secondary="leptin-mediated signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018394" secondary="peptidyl-lysine acetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046628" secondary="positive regulation of insulin receptor signaling pathway" version="SP_204"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1802965" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055089" secondary="fatty acid homeostasis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042981" secondary="regulation of apoptotic process" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9GZR9" version="SP_67" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003000" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990830" secondary="cellular response to leukemia inhibitory factor" version="SP_204"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q96EB6" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001678" secondary="cellular glucose homeostasis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043124" secondary="negative regulation of I-kappaB kinase/NF-kappaB signaling" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000773" secondary="negative regulation of cellular senescence" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042326" secondary="negative regulation of phosphorylation" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5BTR" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" secondary="nucleolus" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005635" secondary="nuclear envelope" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" secondary="chromatin" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR026591" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000720" secondary="pyrimidine dimer repair by nucleotide-excision repair" version="SP_204"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001300978.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070932" secondary="histone H3 deacetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071441" secondary="negative regulation of histone H3-K14 acetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000111" secondary="positive regulation of macrophage apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016239" secondary="positive regulation of macroautophagy" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006642" secondary="triglyceride mobilization" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000212015" version="SP_204" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-427359" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990254" secondary="keratin filament binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000619" secondary="negative regulation of histone H4-K16 acetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043536" secondary="positive regulation of blood vessel endothelial cell migration" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034979" secondary="NAD-dependent protein deacetylase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030225" secondary="macrophage differentiation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031507" secondary="heterochromatin assembly" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9617629" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006346" secondary="DNA methylation-dependent heterochromatin assembly" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006979" secondary="response to oxidative stress" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035358" secondary="regulation of peroxisome proliferator activated receptor signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005677" secondary="chromatin silencing complex" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042393" secondary="histone binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007569" secondary="cell aging" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030512" secondary="negative regulation of transforming growth factor beta receptor signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071456" secondary="cellular response to hypoxia" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000481" secondary="positive regulation of cAMP-dependent protein kinase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051019" secondary="mitogen-activated protein kinase binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106231" secondary="protein-propionyllysine depropionylase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014068" secondary="positive regulation of phosphatidylinositol 3-kinase signaling" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045766" secondary="positive regulation of angiogenesis" version="SP_204"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001135970.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051574" secondary="positive regulation of histone H3-K9 methylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045722" secondary="positive regulation of gluconeogenesis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031393" secondary="negative regulation of prostaglandin biosynthetic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900034" secondary="regulation of cellular response to heat" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010875" secondary="positive regulation of cholesterol efflux" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002821" secondary="positive regulation of adaptive immune response" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043425" secondary="bHLH transcription factor binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071356" secondary="cellular response to tumor necrosis factor" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010906" secondary="regulation of glucose metabolic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051898" secondary="negative regulation of protein kinase B signaling" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032922" secondary="circadian regulation of gene expression" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000757" secondary="negative regulation of peptidyl-lysine acetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001650" secondary="fibrillar center" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042127" secondary="regulation of cell population proliferation" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ZZJ" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033558" secondary="protein deacetylase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902166" secondary="negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051097" secondary="negative regulation of helicase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043280" secondary="positive regulation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044321" secondary="response to leptin" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9707616" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010824" secondary="regulation of centrosome duplication" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KXQ" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IG9" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003713" secondary="transcription coactivator activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017136" secondary="NAD-dependent histone deacetylase activity" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ZZH" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005637" secondary="nuclear inner membrane" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000791" secondary="euchromatin" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106230" secondary="protein depropionylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007346" secondary="regulation of mitotic cell cycle" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002039" secondary="p53 binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016575" secondary="histone deacetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071479" secondary="cellular response to ionizing radiation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000792" secondary="heterochromatin" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR026590" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" secondary="transforming growth factor beta receptor signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016605" secondary="PML body" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901984" secondary="negative regulation of protein acetylation" version="SP_204"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29757N"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-400253" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006325" secondary="chromatin organization" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042595" secondary="behavioral response to starvation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042632" secondary="cholesterol homeostasis" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904179" secondary="positive regulation of adipose tissue development" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032868" secondary="response to insulin" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034391" secondary="regulation of smooth muscle cell apoptotic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016922" secondary="nuclear receptor binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070914" secondary="UV-damage excision repair" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006476" secondary="protein deacetylation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070857" secondary="regulation of bile acid biosynthetic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071900" secondary="regulation of protein serine/threonine kinase activity" version="SP_204"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000212015" version="SP_204" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902237" secondary="positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045348" secondary="positive regulation of MHC class II biosynthetic process" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045739" secondary="positive regulation of DNA repair" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009267" secondary="cellular response to starvation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019213" secondary="deacetylase activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030308" secondary="negative regulation of cell growth" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060907" secondary="positive regulation of macrophage cytokine production" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008134" secondary="transcription factor binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042771" secondary="intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050872" secondary="white fat cell differentiation" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9Y6F0" version="SP_67" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001542" secondary="ovulation from ovarian follicle" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2XNF6" version="SP_67" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001938" secondary="positive regulation of endothelial cell proliferation" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090400" secondary="stress-induced premature senescence" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IF6" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003714" secondary="transcription corepressor activity" version="SP_204"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3371453" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043398" secondary="HLH domain binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046969" secondary="NAD-dependent histone deacetylase activity (H3-K9 specific)" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000012" secondary="single strand break repair" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070829" secondary="heterochromatin maintenance" version="SP_204"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_036370.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990841" secondary="promoter-specific chromatin binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042542" secondary="response to hydrogen peroxide" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043518" secondary="negative regulation of DNA damage response, signal transduction by p53 class mediator" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008022" secondary="protein C-terminus binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033553" secondary="rDNA heterochromatin" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070403" secondary="NAD+ binding" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" secondary="negative regulation of transcription, DNA-templated" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" secondary="positive regulation of protein phosphorylation" version="SP_204"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4I5I" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" secondary="negative regulation of neuron death" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902176" secondary="negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060766" secondary="negative regulation of androgen receptor signaling pathway" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045599" secondary="negative regulation of fat cell differentiation" version="SP_204"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5JVQ0" version="SP_67" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" secondary="cellular response to DNA damage stimulus" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032071" secondary="regulation of endodeoxyribonuclease activity" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007517" secondary="muscle organ development" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000731" secondary="DNA synthesis involved in DNA repair" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000774" secondary="positive regulation of cellular senescence" version="SP_204"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000655" secondary="negative regulation of cellular response to testosterone stimulus" version="SP_204"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029035" version="SP_204"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-16414-1" id="3208870">
                <names>
                    <shortLabel>sirt1-nos3-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-187630E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16414-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15854754" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3208867</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3208871">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15854759" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3208868</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human</shortLabel>
                                    <fullName>Homo sapiens</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Human</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3208872">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15854758" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3208869</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human</shortLabel>
                                    <fullName>Homo sapiens</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Human</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
