DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ kjaer-2010-1 crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Kjaer S., Hanrahan S., Totty N., McDonald NQ. DIP original experiment: DIP-218321X Nature structural & molecular biology 2010 IMEx Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Kjaer S., Hanrahan S., Totty N., McDonald NQ. Only protein-protein interactions imex curation kjaer-2010-2 in vitro In vitro elisa enzyme linked immunosorbent assay ELISA ELISA elisa predetermined predetermined participant predetermined Kjaer S., Hanrahan S., Totty N., McDonald NQ. DIP original experiment: DIP-218322X Nature structural & molecular biology 2010 IMEx Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Kjaer S., Hanrahan S., Totty N., McDonald NQ. Only protein-protein interactions imex curation kjaer-2010-3 in vitro In vitro elisa enzyme linked immunosorbent assay ELISA ELISA elisa predetermined predetermined participant predetermined Kjaer S., Hanrahan S., Totty N., McDonald NQ. DIP original experiment: DIP-218323X Nature structural & molecular biology 2010 IMEx Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Kjaer S., Hanrahan S., Totty N., McDonald NQ. Only protein-protein interactions imex curation ret_human Proto-oncogene tyrosine-protein kinase receptor Ret RET CDHF12 Cadherin family member 12 Proto-oncogene c-Ret CDHR16 PTC RET51 protein protein human Homo sapiens Human MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS p56159-2 GDNF family receptor alpha-1 GFRA1 GDNFRA RETL1 TRNR1 RET ligand 1 TGF-beta-related neurotrophic factor receptor 1 protein protein human Homo sapiens Human MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. p39905-1 Glial cell line-derived neurotrophic factor GDNF Astrocyte-derived trophic factor Ex1_4L protein protein human Homo sapiens Human MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI ret-1 3208835 N/A 3208838 unspecified role unspecified role unspecified role unspecified role CLD1-2 domain Region 1-272 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction false false false gfra1-ret-1 3208836 N/A 3208839 unspecified role unspecified role bait bait Region 19-429 Region 19-429 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false mouse Mus musculus Mouse N/A 3208838 unspecified role unspecified role prey prey Extracellular domain Region 1-636 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false P07949:p.[Arg77Glu;Arg144Asp] R77E/R144D mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human physical association physical association false false false gfra1-gdnf-1 3208837 N/A 3208840 unspecified role unspecified role prey prey Region 109-211 Region 109-211 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false mouse Mus musculus Mouse N/A 3208839 unspecified role unspecified role bait bait Region 19-429 Region 19-429 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false mouse Mus musculus Mouse direct interaction direct interaction false false false