DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ velasco-2010-1 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Velasco G., Hubé F., Rollin J., Neuillet D., Philippe C., Bouzinba-Segard H., Galvani A., Viegas-Péquignot E., Francastel C. DIP original experiment: DIP-219776X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. Velasco G., Hubé F., Rollin J., Neuillet D., Philippe C., Bouzinba-Segard H., Galvani A., Viegas-Péquignot E., Francastel C. Only protein-protein interactions imex curation velasco-2010-2 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Velasco G., Hubé F., Rollin J., Neuillet D., Philippe C., Bouzinba-Segard H., Galvani A., Viegas-Péquignot E., Francastel C. DIP original experiment: DIP-219777X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. Velasco G., Hubé F., Rollin J., Neuillet D., Philippe C., Bouzinba-Segard H., Galvani A., Viegas-Péquignot E., Francastel C. Only protein-protein interactions imex curation dnm3b_mouse DNA (cytosine-5)-methyltransferase 3B Dnmt3b DNA methyltransferase MmuIIIB protein protein mouse Mus musculus Mouse MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE mint Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones e2f6_human Transcription factor E2F6 E2F6 protein protein human Homo sapiens Human MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN e2f6_mouse Transcription factor E2F6 E2f6 E2F-binding site-modulating activity protein protein protein mouse Mus musculus Mouse MSQQRTARRQPSLLVDPAQETVRRRCRDPINVENLLPSKIRINLEENVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIELVEKKSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIAVKAPEETRLDVPAPREDSITVHIRSTKGPIDVYLCEVEQNHSNGKTNDGIGASPSKSSHPQCPEKEDEPPQ e2f6-dnmt3b-1 3208333 N/A 3208335 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3208336 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false e2f6-dnmt3b-2 3208334 N/A 3208335 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3208337 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false