DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ wang-2010-15 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215905X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-16 human Homo sapiens Human tap tandem affinity purification TAP TAP tap predetermined predetermined participant predetermined Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215898X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-17 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215903X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-18 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215901X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-19 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215899X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-20 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215906X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-21 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215907X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-22 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215900X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-23 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215902X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation wang-2010-24 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. DIP original experiment: DIP-215904X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY., Liu LJ., Zhong B., Liu TT., Li Y., Yang Y., Ran Y., Li S., Tien P., Shu HB. Only protein-protein interactions imex curation sting_human Stimulator of interferon genes protein STING1 ERIS Endoplasmic reticulum interferon stimulator MITA Mediator of IRF3 activation TMEM173 Transmembrane protein 173 protein protein human Homo sapiens Human MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS o95786-1 Antiviral innate immune response receptor RIG-I Probable ATP-dependent RNA helicase DDX58 DDX58 DEAD box protein 58 RIG-I-like receptor 1 Retinoic acid-inducible gene 1 protein Retinoic acid-inducible gene I protein protein protein human Homo sapiens Human MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAEMSK traf6_human TNF receptor-associated factor 6 TRAF6 RNF85 Interleukin-1 signal transducer RING finger protein 85 E3 ubiquitin-protein ligase TRAF6 RING-type E3 ubiquitin transferase TRAF6 protein protein human Homo sapiens Human MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV traf3_human TNF receptor-associated factor 3 TRAF3 CAP1 CRAF1 CD40 receptor-associated factor 1 CD40-binding protein LMP1-associated protein 1 CAP-1 RING-type E3 ubiquitin transferase TRAF3 protein protein human Homo sapiens Human MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP q7z434-1 Mitochondrial antiviral-signaling protein MAVS IPS1 KIAA1271 VISA CARD adapter inducing interferon beta Interferon beta promoter stimulator protein 1 Putative NF-kappa-B-activating protein 031N Virus-induced-signaling adapter protein protein human Homo sapiens Human MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH wdr5_human WD repeat-containing protein 5 BMP2-induced 3-kb gene protein WDR5 BIG3 protein protein human Homo sapiens Human MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC mavs-ddx58-8 3202450 N/A 3202460 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202461 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202462 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202463 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202464 unspecified role unspecified role bait bait human Homo sapiens Human association association false false false mavs-wdr5-1 3202451 N/A 3202464 unspecified role unspecified role bait bait TAP-tag TAP-tag tandem tag tandem tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3202465 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false traf3-wdr5-1 3202452 N/A 3202463 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3202465 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false wdr5-traf3-1 3202453 N/A 3202463 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3202465 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false wdr5-mavs-1 3202454 N/A 3202464 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202465 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false mavs-tmem173-2 3202455 N/A 3202460 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202462 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202463 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202464 unspecified role unspecified role bait bait human Homo sapiens Human association association false false false mavs-tmem173-3 3202456 N/A 3202460 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3202464 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false wdr5-mavs-2 3202457 N/A 3202464 unspecified role unspecified role prey prey Region 360-540 Region 360-540 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3202465 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false wdr5-traf6-1 3202458 N/A 3202462 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3202465 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false traf6-wdr5-1 3202459 N/A 3202462 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3202465 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false