DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ kim-2009-24 in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Kim HJ., Lee HJ., Jun JI., Oh Y., Choi SG., Kim H., Chung CW., Kim IK., Park IS., Chae HJ., Kim HR., Jung YK. DIP original experiment: DIP-215978X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53. Kim HJ., Lee HJ., Jun JI., Oh Y., Choi SG., Kim H., Chung CW., Kim IK., Park IS., Chae HJ., Kim HR., Jung YK. Only protein-protein interactions imex curation kim-2009-25 in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Kim HJ., Lee HJ., Jun JI., Oh Y., Choi SG., Kim H., Chung CW., Kim IK., Park IS., Chae HJ., Kim HR., Jung YK. DIP original experiment: DIP-215979X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53. Kim HJ., Lee HJ., Jun JI., Oh Y., Choi SG., Kim H., Chung CW., Kim IK., Park IS., Chae HJ., Kim HR., Jung YK. Only protein-protein interactions imex curation casp3_human Caspase-3 Apopain Cysteine protease CPP32 Protein Yama SREBP cleavage activity 1 CASP3 CPP32 protein protein human Homo sapiens Human MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH p10451-1 Osteopontin SPP1 BNSP OPN Bone sialoprotein 1 Nephropontin Secreted phosphoprotein 1 Urinary stone protein Uropontin PSEC0156 OP1B OPN-a protein protein human Homo sapiens Human MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN casp8_human Caspase-8 CASP8 MCH5 ICE-like apoptotic protease 5 MORT1-associated ced-3 homolog FADD-homologous ICE/ced-3-like protease FADD-like ICE Apoptotic cysteine protease Apoptotic protease Mch-5 CAP4 protein protein human Homo sapiens Human MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD casp3-spp1-1 3195509 N/A 3195511 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli N/A 3195512 enzyme target enzyme target substrate substrate unspecified role unspecified role P10451-1:p.Asp157Ala D157A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false P10451-1:p.[Asp135Ala;Asp157Ala] D135A/D157A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false S35-label S35-label 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false in vitro In vitro protein cleavage protein cleavage false false false casp8-spp1-1 3195510 N/A 3195513 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli N/A 3195512 enzyme target enzyme target substrate substrate unspecified role unspecified role P10451-1:p.[Asp135Ala;Asp157Ala] D135A/D157A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false S35-label S35-label 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Region 1-139 Region 1-139 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro protein cleavage protein cleavage false false false