DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ laurn-2009-1 in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. DIP original experiment: DIP-249830X Nature 2009 IMEx Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM., Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. Only protein-protein interactions imex curation laurn-2009-2 in vitro In vitro sls static light scattering sls predetermined predetermined participant predetermined Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. DIP original experiment: DIP-249834X Nature 2009 IMEx Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM., Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. Only protein-protein interactions imex curation laurn-2009-3 in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. DIP original experiment: DIP-249831X Nature 2009 IMEx Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM., Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. Only protein-protein interactions imex curation laurn-2009-4 in vitro In vitro comigration in sds comigration in sds page comigration in sds western blot western blot Immuno blot Immuno blot Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. DIP original experiment: DIP-249832X Nature 2009 IMEx Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM., Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. Only protein-protein interactions imex curation laurn-2009-5 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. DIP original experiment: DIP-249833X Nature 2009 IMEx Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM., Laurén J., Gimbel DA., Nygaard HB., Gilbert JW., Strittmatter SM. Only protein-protein interactions imex curation p05067-pro_0000000092 Amyloid-beta protein 42 Alzheimer disease amyloid protein Cerebral vascular amyloid peptide APP A4 AD1 ABPP PreA4 Protease nexin-II APPI Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 672 713 prio_mouse Major prion protein PrP27-30 PrP33-35C Prnp Prn-p Prp protein protein mouse Mus musculus Mouse MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG p12023-pro_0000000118 Amyloid-beta protein 42 App ABPP Alzheimer disease amyloid A4 protein homolog Amyloid precursor protein Amyloidogenic glycoprotein A4 AD1 Alzheimer disease amyloid protein Amyloid-beta (A4) precursor protein Amyloid-beta A4 protein protein protein mouse Mus musculus Mouse DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 672 713 abeta42-1 3184916 N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction false false false abeta42-2 3184917 N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction false false false abeta42-3 3184918 N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction false false false abeta42-4 3184919 N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3184921 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction false false false prnp-abeta42-1 3184920 N/A 3184922 unspecified role unspecified role bait bait Region 1-230 Region 1-230 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Fc-tag Fc-tag fusion protein fusion protein c-term range C-terminal range c-term range c-term range C-terminal range c-term range false human Homo sapiens Human N/A 3184923 unspecified role unspecified role prey prey in vitro In vitro direct interaction direct interaction false false false