DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ wang-2009-11 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. DIP original experiment: DIP-133700X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. Only protein-protein interactions imex curation wang-2009-12 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. DIP original experiment: DIP-133696X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. Only protein-protein interactions imex curation wang-2009-13 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. DIP original experiment: DIP-133699X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. Only protein-protein interactions imex curation wang-2009-14 mouse Mus musculus Mouse molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column anti tag western anti tag western blot anti tag western Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. DIP original experiment: DIP-133701X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. Only protein-protein interactions imex curation wang-2009-15 mouse Mus musculus Mouse molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column tag fluorescence tag visualisation by fluorescence tag fluorescence Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. DIP original experiment: DIP-133697X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. Only protein-protein interactions imex curation wang-2009-16 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. DIP original experiment: DIP-133698X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Wang J., Farr GW., Zeiss CJ., Rodriguez-Gil DJ., Wilson JH., Furtak K., Rutkowski DT., Kaufman RJ., Ruse CI., Yates JR., Perrin S., Feany MB., Horwich AL. Only protein-protein interactions imex curation sodc_human Superoxide dismutase [Cu-Zn] Superoxide dismutase 1 SOD1 protein protein human Homo sapiens Human MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ hs71b_mouse Heat shock 70 kDa protein 1B Hspa1b Hcp70.1 Hsp70-1 Hsp70a1 Heat shock 70 kDa protein 1 Hspa1 protein protein mouse Mus musculus Mouse MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPPKGASGSGPTIEEVD hsp72_mouse Heat shock-related 70 kDa protein 2 Hspa2 Hcp70.2 Hsp70-2 protein protein mouse Mus musculus Mouse MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYLGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSSGGPTIEEVD hsp7c_mouse Heat shock cognate 71 kDa protein Heat shock 70 kDa protein 8 Hspa8 Hsc70 Hsc73 protein protein mouse Mus musculus Mouse MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD ccs_mouse Copper chaperone for superoxide dismutase Ccsd Superoxide dismutase copper chaperone Ccs protein protein mouse Mus musculus Mouse MASKSGDGGTVCALEFAVQMSCQSCVDAVHKTLKGVAGVQNVDVQLENQMVLVQTTLPSQEVQALLESTGRQAVLKGMGSSQLQNLGAAVAILEGCGSIQGVVRFLQLSSELCLIEGTIDGLEPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKVWDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGQGRKDSAQPPAHL sodc_mouse Superoxide dismutase [Cu-Zn] Sod1 protein protein mouse Mus musculus Mouse MAMKAVCVLKGDGPVQGTIHFEQKASGEPVVLSGQITGLTEGQHGFHVHQYGDNTQGCTSAGPHFNPHSKKHGGPADEERHVGDLGNVTAGKDGVANVSIEDRVISLSGEHSIIGRTMVVHEKQDDLGKGGNEESTKTGNAGSRLACGVIGIAQ dnja1_mouse DnaJ homolog subfamily A member 1 Heat shock 40 kDa protein 4 DnaJ protein homolog 2 Heat shock protein J2 Dnaja1 Dnaj2 Hsj2 Hspf4 protein protein mouse Mus musculus Mouse MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS bip_mouse Endoplasmic reticulum chaperone BiP Immunoglobulin heavy chain-binding protein Hspa5 Grp78 78 kDa glucose-regulated protein Binding-immunoglobulin protein Heat shock protein 70 family protein 5 Heat shock protein family A member 5 protein protein mouse Mus musculus Mouse MMKFTVVAAALLLLGAVRAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSGGPPPTGEEDTSEKDEL hsp74_mouse Heat shock 70 kDa protein 4 Hspa4 Apg2 Hsp110 Heat shock 70-related protein APG-2 protein protein mouse Mus musculus Mouse MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNKGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSVLEQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGLSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQNAKEEEKMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPPQAKKAKVKTSTVDLPIEHTLWQLDREMLALYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTRFQESEERPKLFEELGKQIQQYMKVISSFKNKEDQYEHLDAADVTKVEKSTNEAMEWMNSKLNLQNKQSLTVDPVVKTKEIEAKIKELTSICSPIISKPKPKVEPPKEEPKHAEQNGPVDGQGDNPGSQAAEHGADTAVPSDGDKKLPEMDID hs105_mouse Heat shock protein 105 kDa Heat shock-related 100 kDa protein E7I Heat shock 110 kDa protein 42 degrees C-HSP Hsph1 Hsp105 Hsp110 Kiaa0201 protein protein mouse Mus musculus Mouse MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNIDKKEDLEGKNNLGAEAPHQNGECHPNEKGSVNMDLD sod1-ccs-1 3183260 N/A 3183266 unspecified role unspecified role bait bait YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse N/A 3183267 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183268 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183269 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183270 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183271 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association false false false sod1-ccs-2 3183261 N/A 3183266 unspecified role unspecified role bait bait YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse N/A 3183272 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183273 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183274 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183275 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183267 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183268 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183269 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183270 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183271 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association false false false sod1-ccs-3 3183262 N/A 3183266 unspecified role unspecified role bait bait YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse N/A 3183273 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183275 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183267 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183268 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183269 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183270 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183271 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association false false false sod1-10 3183263 N/A 3183266 unspecified role unspecified role unspecified role unspecified role YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse direct interaction direct interaction false false false sod1-11 3183264 N/A 3183266 unspecified role unspecified role unspecified role unspecified role YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false P00441:p.Gly86Arg G86R mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false mouse Mus musculus Mouse direct interaction direct interaction false false false sod1-ccs-4 3183265 N/A 3183266 unspecified role unspecified role bait bait YFP-tag YFP-tag yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse N/A 3183273 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183274 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183275 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183267 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183269 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183270 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3183271 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association false false false