DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ lin-2008-12 in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132178X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions imex curation lin-2008-13 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132180X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions imex curation lin-2008-14 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132179X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions imex curation lin-2008-15 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132181X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions imex curation irak1_human Interleukin-1 receptor-associated kinase 1 IRAK1 IRAK protein protein human Homo sapiens Human MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS peli1_mouse E3 ubiquitin-protein ligase pellino homolog 1 Peli1 RING-type E3 ubiquitin transferase pellino homolog 1 protein protein mouse Mus musculus Mouse MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERSPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD q8n2h9-2 E3 ubiquitin-protein ligase pellino homolog 3 PELI3 RING-type E3 ubiquitin transferase pellino homolog 3 B Beta protein protein human Homo sapiens Human MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD peli2_human E3 ubiquitin-protein ligase pellino homolog 2 PELI2 RING-type E3 ubiquitin transferase pellino homolog 2 protein protein human Homo sapiens Human MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID rad9 (pt192) Rad9 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) WSLEVTEADT peli1-irak1-3 3181644 N/A 3181648 unspecified role unspecified role prey prey Xpress-tag Xpress-tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3181649 unspecified role unspecified role bait bait Region 2-287 Region 2-287 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli physical association physical association false false false peli3-irak1-5 3181645 N/A 3181650 unspecified role unspecified role bait bait Region 2-313 Region 2-313 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecolx Escherichia coli N/A 3181648 unspecified role unspecified role prey prey Xpress-tag Xpress-tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false peli2-irak1-3 3181646 N/A 3181651 unspecified role unspecified role bait bait Region 15-275 Region 15-275 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false Q9HAT8:p.Arg106Ala R106A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q9HAT8:p.[Thr187Ala;Asn188Ala] T187A/N188A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3181648 unspecified role unspecified role prey prey Xpress-tag Xpress-tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false rad9 (pt192)-peli2-1 3181647 N/A 3181652 unspecified role unspecified role bait bait pT6 pT6 opthr O-phospho-L-threonine (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)butanoic acid MOD_RES Phosphothreonine O-phospho-L-threonine O-phosphorylated L-threonine O3-phosphothreonine threonine phosphate ester OPThr Phospho Phospho Threonyl Phosphorylation phosphorylationt certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3181651 unspecified role unspecified role prey prey Q9HAT8:p.Arg106Ala R106A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false