DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ oshima-2009-1 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249778X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-2 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249782X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-3 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249774X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-4 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249780X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-5 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249776X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-6 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249775X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-7 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249779X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-8 in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249781X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation oshima-2009-9 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. DIP original experiment: DIP-249777X Nature 2009 IMEx ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Oshima S., Turer EE., Callahan JA., Chai S., Advincula R., Barrera J., Shifrin N., Lee B., Benedict Yen TS., Woo T., Malynn BA., Ma A. Only protein-protein interactions imex curation casp8_human Caspase-8 CASP8 MCH5 ICE-like apoptotic protease 5 MORT1-associated ced-3 homolog FADD-homologous ICE/ced-3-like protease FADD-like ICE Apoptotic cysteine protease Apoptotic protease Mch-5 CAP4 protein protein human Homo sapiens Human MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD fadd_human FAS-associated death domain protein FAS-associating death domain-containing protein Mediator of receptor induced toxicity FADD MORT1 GIG3 Growth-inhibiting gene 3 protein protein protein human Homo sapiens Human MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG tnip1_mouse TNFAIP3-interacting protein 1 Tnip1 Abin Naf1 Nef-associated factor 1 Virion-associated nuclear shuttling protein A20-binding inhibitor of NF-kappa-B activation 1 protein protein mouse Mus musculus Mouse MEGRGPYRIYDPGGSTPLGEVSAAFERLVEENTRLKGKMQGIKMLGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPATSTAATTTATATTGNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDLGPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQPSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLEQQRMELLEVNKQWDQHFRSMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVRYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQASPSSPPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTNAQLKTLKEEEKAKEALKQQKRKAKASGERYHMEPHPEHVCGAYPYAYPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRNQSSQVMDPPPDRPAEPESADNDCDGPQ ripk1_human Receptor-interacting serine/threonine-protein kinase 1 RIPK1 RIP Cell death protein RIP RIP1 Receptor-interacting protein 1 protein protein human Homo sapiens Human MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN tnap3_mouse Tumor necrosis factor alpha-induced protein 3 Putative DNA-binding protein A20 Zinc finger protein A20 Tnfaip3 Tnfip3 protein protein mouse Mus musculus Mouse MAEQLLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIYHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRSVQASLESQKKLNWCREVRKLVALKTNGDGNCLMHAACQYMWGVQDTDLVLRKALCSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLVKMASADTPAARSGLQYNSLEEIHIFVLSNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSQHFVPLVTLKDSGPELRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLIVMEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSDQARRAAHAQNPLEPSTPQLSLMDIKCETPNCPFFMSVNTQPLCHECSERRQKNQSKLPKLNSKLGPEGLPGVGLGSSNWSPEETAGGPHSAPPTAPSLFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHARQINASHTADPGKCQACLQDVTRTFNGICSTCFKRTTAEPSSSLTSSIPASCHQRSKSDPSQLIQSLTPHSCHRTGNVSPSGCLSQAARTPGDRAGTSKCRKAGCMYFGTPENKGFCTLCFIEYRENKQSVTASEKAGSPAPRFQNNVPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEARRTEEQLRSSQHRDMPRTTQVASRLKCARASCKNILACRSEELCMECQHLSQRVGSVAHRGEPTPEEPPKQRCRAPACDHFGNAKCNGYCNECYQFKQMYG tnap3_human Tumor necrosis factor alpha-induced protein 3 Putative DNA-binding protein A20 Zinc finger protein A20 TNFAIP3 OTUD7C OTU domain-containing protein 7C protein protein human Homo sapiens Human MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTPMARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSEQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPKLNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCFKRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGDRTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARASCKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCNECFQFKQMYG casp8-fadd-8 3181240 N/A 3181249 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3181250 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false ub-tnip1-1 3181241 N/A 3181251 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false ecolx Escherichia coli N/A 3181252 unspecified role unspecified role prey prey Region 474-647 Region 474-647 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli direct interaction direct interaction false false false tnip1-fadd-1 3181242 N/A 3181252 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3181253 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3181250 unspecified role unspecified role prey prey human Homo sapiens Human association association false false false tnip1-tnfaip3-1 3181243 N/A 3181254 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3181252 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false mouse Mus musculus Mouse physical association physical association false false false casp8-ripk1-7 3181244 N/A 3181249 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3181255 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3181253 unspecified role unspecified role prey prey human Homo sapiens Human association association false false false casp8-fadd-19 3181245 N/A 3181249 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3181255 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3181253 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3181250 unspecified role unspecified role prey prey human Homo sapiens Human association association false false false tnip1-fadd-2 3181246 N/A 3181252 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Q9WUU8:p.[Gln477Glu;Gln478Glu] Q477E/Q478E mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false human Homo sapiens Human N/A 3181253 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3181250 unspecified role unspecified role prey prey human Homo sapiens Human association association false false false tnip1-ub-1 3181247 N/A 3181251 unspecified role unspecified role prey prey His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false ecolx Escherichia coli N/A 3181252 unspecified role unspecified role bait bait Region 474-647 Region 474-647 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false Q9WUU8:p.[Gln477Glu;Gln478Glu] Q477E/Q478E mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false Q9WUU8:p.Phe482Ser F482S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli direct interaction direct interaction false false false casp8-tnfaip3-1 3181248 N/A 3181249 unspecified role unspecified role bait bait human Homo sapiens Human N/A 3181255 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false