DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dohi-2008-1 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113515X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation dohi-2008-2 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113521X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation dohi-2008-3 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip ms participant Identification by mass spectrometry ms participant Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113520X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation dohi-2008-4 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113516X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation dohi-2008-5 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113519X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation dohi-2008-6 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113518X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation dohi-2008-7 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. DIP original experiment: DIP-113517X Nature structural & molecular biology 2008 IMEx Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Dohi Y., Ikura T., Hoshikawa Y., Katoh Y., Ota K., Nakanome A., Muto A., Omura S., Ohta T., Ito A., Yoshida M., Noda T., Igarashi K. Only protein-protein interactions imex curation mafk_mouse Transcription factor MafK Mafk Nfe2u Erythroid transcription factor NF-E2 p18 subunit protein protein mouse Mus musculus Mouse MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS bach1_mouse Transcription regulator protein BACH1 BTB and CNC homolog 1 Bach1 protein protein mouse Mus musculus Mouse MSVSESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFLDSTSEQQECARKKCFSSHCQKADFKFSFSEQKDLEIDEADEFLEKKRVQTPQCDSRRCQGSVKASPPLQDSVSQACQSLCTDKDGALALPSLCPKYRKFQKAFGTDKIRTLESGVRDVHTASVQPNETSELECFGGAQGCADLHVILKCEGMKAAMESEDTEGQDPSPQCPAEQPQGTPLPQDSAGPHGLYSLSALHTYEQSGDVAFAGVQSKTVKTEKPLSRPDAQDEKPSENQDLYLKSSMGPKEDSSSLASEDRSSVEREVAEHLAKGFWSDICSTDSPCQMQLSPTVAKDGPEQGYSQRRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSSEGCSSNLEIGNYDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQDCEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQQVCKEAALSPEQIQILAKYSASDCPLSFLISEKGKSTPDGELAFTSVFSVSDVPPTAPPPCGRGSSAASQELVQESPPTTAAAPEQATLLEPCRQSAGISDFCQQMSDKCTTDE mafg_mouse Transcription factor MafG Mafg V-maf musculoaponeurotic fibrosarcoma oncogene homolog G protein protein mouse Mus musculus Mouse MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQNFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS mint Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2 hmmr_mouse Hyaluronan mediated motility receptor Hmmr Ihabp Rhamm Intracellular hyaluronic acid-binding protein Receptor for hyaluronan-mediated motility protein protein mouse Mus musculus Mouse MSFPKAPLKRFNDPSGCAPSPGAYDVKTSEATKGPVSFQKSQRFKNQRESQQNLNIDKDTTLLASAKKAKKSVSKKDSQKNDKDVKRLEKEIRALLQERGTQDKRIQDMESELEKTEAKLNAAVREKTSLSASNASLEKRLTELTRANELLKAKFSEDGHQKNMRALSLELMKLRNKRETKMRSMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLVSIEKEKIDEKCETEKLLEYIQEISCASDQVEKCKVDIAQLEEDLKEKDREILSLKQSLEENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYEKLQQKELQSQSLLQQEKELSARLQQQLCSFQEEMTSEKNVFKEELKLALAELDAVQQKEEQSERLVKQLEEETKSTAEQLTRLDNLLREKEVELEKHIAAHAQAILIAQEKYNDTAQSLRDVTAQLESVQEKYNDTAQSLRDVTAQLESEQEKYNDTAQSLRDVTAQLESEQEKYNDTAQSLRDVTAQLESVQEKYNDTAQSLRDVTAQLESYKSSTLKEIEDLKLENLTLQEKVAMAEKSVEDVQQQILTAESTNQEYARMVQDLQNRSTLKEEEIKEITSSFLEKITDLKNQLRQQDEDFRKQLEEKGKRTAEKENVMTELTMEINKWRLLYEELYEKTKPFQQQLDAFEAEKQALLNEHGATQEQLNKIRDSYAQLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRSQLVKRKQNELRLQGELDKALGIRHFDPSKAFCHASKENFTPLKEGNPNCC ncor1_mouse Nuclear receptor corepressor 1 Ncor1 Rxrip13 Retinoid X receptor-interacting protein 13 protein protein mouse Mus musculus Mouse MSSSGYPPNQGAFSTEQSRYPSHSVQYTFPSARHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRSGYEQFHPGPSPVDHDSLESKRPRLEQVSDSHFQRISAAVLPLVHTLPEGLRSSANAKKDPAFGVKHEAPSSPLSGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDDEEKDDKEDSKETTKEKDRTEATAEEPEEREQVTPRGRKTANSQGRGKGRVTRSMTSEAAAANAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKASRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKPAERESVEAQVTDSASAETAEPMDVDHEECGAEGSSVLDPPAPTKADSVDPEMQVPENTASKGEGDAKERDLESTSEKTEARDEDVVVAEQIERPEPQSDDDSSATCSADEGVDGEPERQRVFPMDAKPSLLTPPGSILISSPIKPNLLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQVDLECRSSTSPCSTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLSSHNQAYPQEAPKPSVGSISLGLPRQQESTKAAPLTYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAVQEGSITRGTPASKISVETISSLRGSITQGTPALPQAGIPTEALVKGPVSRMPIEESSPEKVREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEMSLKRSYEAVEGSIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATAESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLPRGMLEIVPENIKVVERGKYEDVKAGEPVRARHTSVVSSGPSVLRSTLHEAPKAQLSPGLYDDSSARRTPVSYQNTISRGSPMMNRTSDVSSSKSASHERKSTLTPTQRESIPAKSPVPGVDPIVSHSPFDPHHRSSAAGEVYRSHLPTHLDPAMPFHRALDPAAAYLLQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVTRGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHAGGTSTPPMDRITYIPGTQVTFPPRPYNAASLSPGHPTHLAAAASAEREREREREKERERERERERERERERIAAAPADLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETILQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPSGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKNLEVEKRSVQCVCTSSALPSGKAQPHASVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYETASDAIEVISPASSPAPPQEKPQAYQPDMVKANQAENESTRQYEGPLHHYRSQQESPSPQQQPPLPPSSQSEGMGQVPRTHRLITLADHICQIITQDFARNQVPSQASTSTFQTSPSALSSTPVRTKTSSRYSPESQSQTVLHPRPGPRVSPENLVDKSRGSRPGKSPERSHIPSEPYEPISPPQGPAVHEKQDSMLLLSQRGVDPAEQRSDSRSPGSISYLPSFFTKLESTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGAVSSRSHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSHPVGIMPGSASTSVVTSSEARRDEGEPSPHAGVCKPKLINKSNSRKSKSPIPGQSYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTIRMLSSTPPTQIACAPSAITQAAPHQQNRIWEREPAPLLSAQYETLSDSDD p53_mouse Cellular tumor antigen p53 Tp53 P53 Trp53 Tumor suppressor p53 protein protein mouse Mus musculus Mouse MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD hdac1_mouse Histone deacetylase 1 Hdac1 protein protein mouse Mus musculus Mouse MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA bach1-mafk-1 3180146 N/A 3180153 unspecified role unspecified role prey prey MBP-tag MBP-tag mbp tag maltose binding protein tag maltose binding protein tag maltose binding protein tag mbp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3180154 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli direct interaction direct interaction false false false bach1-hmmr-1 3180147 N/A 3180155 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180156 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180153 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180157 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180154 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse association association false false false bach1-hmmr-2 3180148 N/A 3180155 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180156 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180153 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180157 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180154 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse association association false false false tp53-bach1-1 3180149 N/A 3180154 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180158 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false bach1-hdac1-1 3180150 N/A 3180153 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180159 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180157 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180154 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse N/A 3180158 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association false false false bach1-hdac1-2 3180151 N/A 3180153 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180159 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180157 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180154 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false mouse Mus musculus Mouse N/A 3180158 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association false false false tp53-bach1-2 3180152 N/A 3180153 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180159 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180157 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180154 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3180158 unspecified role unspecified role bait bait mouse Mus musculus Mouse association association false false false