DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ stegh-2008-1 in vitro In vitro pull down pull down predetermined predetermined participant predetermined Stegh AH., Kesari S., Mahoney JE., Jenq HT., Forloney KL., Protopopov A., Louis DN., Chin L., DePinho RA. DIP original experiment: DIP-133189X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Stegh AH., Kesari S., Mahoney JE., Jenq HT., Forloney KL., Protopopov A., Louis DN., Chin L., DePinho RA. Only protein-protein interactions imex curation stegh-2008-2 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Stegh AH., Kesari S., Mahoney JE., Jenq HT., Forloney KL., Protopopov A., Louis DN., Chin L., DePinho RA. DIP original experiment: DIP-133190X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Stegh AH., Kesari S., Mahoney JE., Jenq HT., Forloney KL., Protopopov A., Louis DN., Chin L., DePinho RA. Only protein-protein interactions imex curation stegh-2008-3 in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Stegh AH., Kesari S., Mahoney JE., Jenq HT., Forloney KL., Protopopov A., Louis DN., Chin L., DePinho RA. DIP original experiment: DIP-133191X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Stegh AH., Kesari S., Mahoney JE., Jenq HT., Forloney KL., Protopopov A., Louis DN., Chin L., DePinho RA. Only protein-protein interactions imex curation cryab_human Alpha-crystallin B chain CRYAB CRYA2 Renal carcinoma antigen NY-REN-27 Alpha(B)-crystallin Rosenthal fiber component Heat shock protein beta-5 HSPB5 protein protein human Homo sapiens Human MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK AE08BED46B7849CB casp3_human Caspase-3 Apopain Cysteine protease CPP32 Protein Yama SREBP cleavage activity 1 CASP3 CPP32 protein protein human Homo sapiens Human MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH cryab_mouse Alpha-crystallin B chain Cryab Crya2 Alpha(B)-crystallin P23 protein protein mouse Mus musculus Mouse MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVAAAPKK casp3_mouse Caspase-3 Casp3 Cpp32 Apopain Cysteine protease CPP32 Protein Yama SREBP cleavage activity 1 LICE protein protein mouse Mus musculus Mouse MENNKTSVDSKSINNFEVKTIHGSKSVDSGIYLDSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSSFVCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYFYH casp8_human Caspase-8 CASP8 MCH5 ICE-like apoptotic protease 5 MORT1-associated ced-3 homolog FADD-homologous ICE/ced-3-like protease FADD-like ICE Apoptotic cysteine protease Apoptotic protease Mch-5 CAP4 protein protein human Homo sapiens Human MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD cryab-casp3-1 3175424 N/A 3175427 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false ecolx Escherichia coli N/A 3175428 unspecified role unspecified role prey prey in vitro In vitro direct interaction direct interaction false false false casp3-cryab-1 3175425 N/A 3175429 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3175430 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false casp3-casp8-1 3175426 N/A 3175431 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli N/A 3175428 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro direct interaction direct interaction false false false