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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3173443">
                <names>
                    <shortLabel>fouladkou-2008-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18562292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-111155X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0803233105" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9380" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15710622" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10090">
                        <names>
                            <shortLabel>mouse</shortLabel>
                            <fullName>Mus musculus</fullName>
                            <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Fouladkou F., Landry T., Kawabe H., Neeb A., Lu C., Brose N., Stambolic V., Rotin D.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-111155X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Fouladkou F.,  Landry T.,  Kawabe H.,  Neeb A.,  Lu C.,  Brose N.,  Stambolic V.,  Rotin D.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="3173444">
                <names>
                    <shortLabel>fouladkou-2008-2</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18562292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-111156X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0803233105" refType="primary-reference" refTypeAc="MI:0358"/>
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                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9380" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>pull down</shortLabel>
                        <fullName>pull down</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0096" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1223" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Fouladkou F., Landry T., Kawabe H., Neeb A., Lu C., Brose N., Stambolic V., Rotin D.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-111156X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Fouladkou F.,  Landry T.,  Kawabe H.,  Neeb A.,  Lu C.,  Brose N.,  Stambolic V.,  Rotin D.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3173445">
                <names>
                    <shortLabel>ubiq_mouse</shortLabel>
                    <fullName>Ubiquitin</fullName>
                    <alias typeAc="MI:0301" type="gene name">Rps27a</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Uba80</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ubcep1</alias>
                    <alias typeAc="MI:0301" type="gene name">Uba52</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ubcep2</alias>
                    <alias typeAc="MI:0301" type="gene name">Ubb</alias>
                    <alias typeAc="MI:0301" type="gene name">Ubc</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P62991" version="SP_48" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019954"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q29120" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_075626.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000020460"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P02249" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9ET24" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_077239.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q62317" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9CZM0" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9Z0H9" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P02248" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3A1Q"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3A9K"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_035794.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000055553"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_889611.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9CXY4" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-413074" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000008348"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000058838"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019956"/>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000626" secondary="Ubiquitin"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000068240"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001029037.1"/>
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                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29742N" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019955"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9ET23" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2ZNV"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_001481004.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634"/>
                    <secondaryRef db="ipi" dbAc="MI:0675" id="IPI00750889"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005515"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8VCH1" version="SP_48" refType="secondary-ac" refTypeAc="MI:0360"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG</sequence>
            </interactor>
            <interactor id="3173446">
                <names>
                    <shortLabel>pten_mouse</shortLabel>
                    <fullName>Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Mutated in multiple advanced cancers 1</alias>
                    <alias typeAc="MI:0301" type="gene name">Pten</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Mmac1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Phosphatase and tensin homolog</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="O08586" version="SP_72" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106306" secondary="protein serine phosphatase activity" version="SP_205"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1186266" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033032" secondary="regulation of myeloid cell apoptotic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032869" secondary="cellular response to insulin stimulus" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_205"/>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-199418" version="SP_205"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060997" secondary="dendritic spine morphogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_205"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046685" secondary="response to arsenic-containing substance" version="SP_205"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016311" secondary="dephosphorylation" version="SP_205"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990381" secondary="ubiquitin-specific protease binding" version="SP_205"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007611" secondary="learning or memory" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048738" secondary="cardiac muscle tissue development" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071361" secondary="cellular response to ethanol" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046621" secondary="negative regulation of organ growth" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010977" secondary="negative regulation of neuron projection development" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051898" secondary="negative regulation of protein kinase B signaling" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004721" secondary="phosphoprotein phosphatase activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032228" secondary="regulation of synaptic transmission, GABAergic" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060341" secondary="regulation of cellular localization" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0021542" secondary="dentate gyrus development" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990782" secondary="protein tyrosine kinase binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036294" secondary="cellular response to decreased oxygen levels" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010666" secondary="positive regulation of cardiac muscle cell apoptotic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014823" secondary="response to activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046856" secondary="phosphatidylinositol dephosphorylation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050771" secondary="negative regulation of axonogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099524" secondary="postsynaptic cytosol" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070373" secondary="negative regulation of ERK1 and ERK2 cascade" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029023" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071257" secondary="cellular response to electrical stimulus" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016314" secondary="phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014020" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000387" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060074" secondary="synapse maturation" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1660499" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006470" secondary="protein dephosphorylation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904668" secondary="positive regulation of ubiquitin protein ligase activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904706" secondary="negative regulation of vascular associated smooth muscle cell proliferation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045211" secondary="postsynaptic membrane" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042711" secondary="maternal behavior" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032535" secondary="regulation of cellular component size" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043542" secondary="endothelial cell migration" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000340" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097105" secondary="presynaptic membrane assembly" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" secondary="apical plasma membrane" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016477" secondary="cell migration" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004722" secondary="protein serine/threonine phosphatase activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033198" secondary="response to ATP" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009749" secondary="response to glucose" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045792" secondary="negative regulation of cell size" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q542G1" version="SP_72" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8948751" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044320" secondary="cellular response to leptin stimulus" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000013807" version="SP_205" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050680" secondary="negative regulation of epithelial cell proliferation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050821" secondary="protein stabilization" version="SP_205"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="O08586" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043197" secondary="dendritic spine" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090394" secondary="negative regulation of excitatory postsynaptic potential" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016605" secondary="PML body" version="SP_205"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_032986.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051800" secondary="phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106307" secondary="protein threonine phosphatase activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005161" secondary="platelet-derived growth factor receptor binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051548" secondary="negative regulation of keratinocyte migration" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051895" secondary="negative regulation of focal adhesion assembly" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5689896" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060070" secondary="canonical Wnt signaling pathway" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001933" secondary="negative regulation of protein phosphorylation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043220" secondary="Schmidt-Lanterman incisure" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007270" secondary="neuron-neuron synaptic transmission" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060134" secondary="prepulse inhibition" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000134" secondary="negative regulation of G1/S transition of mitotic cell cycle" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051091" secondary="positive regulation of DNA-binding transcription factor activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043005" secondary="neuron projection" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016130" version="SP_205"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-38740N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903690" secondary="negative regulation of wound healing, spreading of epidermal cells" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048853" secondary="forebrain morphogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001235" secondary="positive regulation of apoptotic signaling pathway" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035176" secondary="social behavior" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032286" secondary="central nervous system myelin maintenance" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061002" secondary="negative regulation of dendritic spine morphogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" secondary="regulation of cell cycle" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901017" secondary="negative regulation of potassium ion transmembrane transporter activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043491" secondary="protein kinase B signaling" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060736" secondary="prostate gland growth" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030534" secondary="adult behavior" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032355" secondary="response to estradiol" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051896" secondary="regulation of protein kinase B signaling" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002902" secondary="regulation of B cell apoptotic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0021955" secondary="central nervous system neuron axonogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000060" secondary="positive regulation of ubiquitin-dependent protein catabolic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007584" secondary="response to nutrient" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048008" secondary="platelet-derived growth factor receptor signaling pathway" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009898" secondary="cytoplasmic side of plasma membrane" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035749" secondary="myelin sheath adaxonal region" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048854" secondary="brain morphogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060044" secondary="negative regulation of cardiac muscle cell proliferation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048870" secondary="cell motility" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000013807" version="SP_205" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014065" secondary="phosphatidylinositol 3-kinase signaling" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033555" secondary="multicellular organismal response to stress" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_205"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV</sequence>
            </interactor>
            <interactor id="3173447">
                <names>
                    <shortLabel>lapm5_mouse</shortLabel>
                    <fullName>Lysosomal-associated transmembrane protein 5</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Lysosomal-associated multitransmembrane protein 5</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Retinoic acid-inducible E3 protein</alias>
                    <alias typeAc="MI:0301" type="gene name">Laptm5</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q61168" version="SP_50" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000028581" version="SP_147" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060907" secondary="positive regulation of macrophage cytokine production" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005765" secondary="lysosomal membrane" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0140311" secondary="protein sequestering activity" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050860" secondary="negative regulation of T cell receptor signaling pathway" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032703" secondary="negative regulation of interleukin-2 production" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_147"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-911973" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032689" secondary="negative regulation of interferon-gamma production" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" secondary="activation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032735" secondary="positive regulation of interleukin-12 production" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030133" secondary="transport vesicle" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043410" secondary="positive regulation of MAPK cascade" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000060" secondary="positive regulation of ubiquitin-dependent protein catabolic process" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061462" secondary="protein localization to lysosome" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002357" secondary="defense response to tumor cell" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031398" secondary="positive regulation of protein ubiquitination" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097214" secondary="positive regulation of lysosomal membrane permeability" version="SP_147"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018396" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050869" secondary="negative regulation of B cell activation" version="SP_147"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-37698N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903052" secondary="positive regulation of proteolysis involved in cellular protein catabolic process" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000646" secondary="positive regulation of receptor catabolic process" version="SP_147"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018397" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032755" secondary="positive regulation of interleukin-6 production" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903265" secondary="positive regulation of tumor necrosis factor-mediated signaling pathway" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" secondary="perinuclear region of cytoplasm" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0140036" secondary="ubiquitin-dependent protein binding" version="SP_147"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000151698" version="SP_147" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0012502" secondary="induction of programmed cell death" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005764" secondary="lysosome" version="SP_147"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q60923" version="SP_50" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006886" secondary="intracellular protein transport" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050868" secondary="negative regulation of T cell activation" version="SP_147"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004687" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904093" secondary="negative regulation of autophagic cell death" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090160" secondary="Golgi to lysosome transport" version="SP_147"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_017175490.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990830" secondary="cellular response to leukemia inhibitory factor" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006622" secondary="protein targeting to lysosome" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0140646" secondary="negative regulation of pre-B cell receptor expression" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901224" secondary="positive regulation of NIK/NF-kappaB signaling" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031410" secondary="cytoplasmic vesicle" version="SP_147"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046007" secondary="negative regulation of activated T cell proliferation" version="SP_147"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034816.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000118415" version="SP_147" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002720" secondary="positive regulation of cytokine production involved in immune response" version="SP_147"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q61168" version="SP_147"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MASRAAPVRQTCCCFNIRVATIALAIYHIVMSVLLFIEHVVEVARGKVSCRFFKMPYLRMADLLSSFLLIGVLFIISISLLFGVVKNREKYLIPFLSLQIMDFLLCLLTLLGSYIELPAYLKLARPRPGPSKVPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEGVPHSQFINMMLIFSVAFITVLILKVYMFKCVYTCYKFLKHMNSAMEDSSSKMFLKVALPSYEEALSLPPKTPEGDPAPPPYSEV</sequence>
            </interactor>
            <interactor id="3173448">
                <names>
                    <shortLabel>nedd4_mouse</shortLabel>
                    <fullName>E3 ubiquitin-protein ligase NEDD4</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Neural precursor cell expressed developmentally down-regulated protein 4</alias>
                    <alias typeAc="MI:0301" type="gene name">Nedd4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Kiaa0093</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Nedd-4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Nedd4a</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">HECT-type E3 ubiquitin transferase NEDD4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Nedd4-1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P46935" version="SP_76" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003197" secondary="endocardial cushion development" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000008" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048514" secondary="blood vessel morphogenesis" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-983168" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8BGB3" version="SP_76" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043161" secondary="proteasome-mediated ubiquitin-dependent protein catabolic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002250" secondary="adaptive immune response" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001202" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019871" secondary="sodium channel inhibitor activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099524" secondary="postsynaptic cytosol" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035983" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_205"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P46935" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006511" secondary="ubiquitin-dependent protein catabolic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030948" secondary="negative regulation of vascular endothelial growth factor receptor signaling pathway" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050815" secondary="phosphoserine residue binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004842" secondary="ubiquitin-protein transferase activity" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1169408" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007528" secondary="neuromuscular junction development" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032801" secondary="receptor catabolic process" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8948747" version="SP_205"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3M7F" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031175" secondary="neuron projection development" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8948751" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000034740" version="SP_205" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" secondary="glutamatergic synapse" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000209" secondary="protein polyubiquitination" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043197" secondary="dendritic spine" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035892" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050807" secondary="regulation of synapse organization" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000650" secondary="negative regulation of sodium ion transmembrane transporter activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045732" secondary="positive regulation of protein catabolic process" version="SP_205"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-773516" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005902" secondary="microvillus" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035255" secondary="ionotropic glutamate receptor binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050816" secondary="phosphothreonine residue binding" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000569" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006513" secondary="protein monoubiquitination" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070064" secondary="proline-rich region binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000151" secondary="ubiquitin ligase complex" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048814" secondary="regulation of dendrite morphogenesis" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099576" secondary="regulation of protein catabolic process at postsynapse, modulating synaptic transmission" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q3UZI2" version="SP_76" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099149" secondary="regulation of postsynaptic neurotransmitter receptor internalization" version="SP_205"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_035020.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031623" secondary="receptor internalization" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1253288" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036020" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008022" secondary="protein C-terminus binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061630" secondary="ubiquitin protein ligase activity" version="SP_205"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-32323N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042110" secondary="T cell activation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010766" secondary="negative regulation of sodium ion transport" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O08758" version="SP_76" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070534" secondary="protein K63-linked ubiquitination" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003151" secondary="outflow tract morphogenesis" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000032216" version="SP_205" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024928" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000034740" version="SP_205" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MSSDMAADESEAPVLSEDEVWEFCLDKTEDGGGSPGSDVTDTCEPPCGCWELNPNSLEEEHVLFTADPYLELHNDDTRVVRVKVIAGIGLAKKDILGASDPYVRVTLYDPMSGILTSVQTKTIKKSLNPKWNEEILFRVLPQRHRILFEVFDENRLTRDDFLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKNGSEDENADQAEELEPGWVVLDQPDAATHLPHPPEPSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSPDDDLTDEDNDDMQLQAQRAFTTRRQISEDVDGPDNRESPENWEIVREDENTEYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVCGNPATSQPVTSSNHSSRGGSLQTCIFEEQPTLPVLLPTSSGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-9380-1" id="3173449">
                <names>
                    <shortLabel>pten-ub-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-87943E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9380-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15710633" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3173443</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3173450">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15710638" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3173445</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3173451">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15710637" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3173446</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-9380-2" id="3173452">
                <names>
                    <shortLabel>laptm5-nedd4-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-87944E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9380-2" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15710650" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3173444</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3173453">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15710655" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3173447</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3173454">
                                <names>
                                    <shortLabel>Region 225-260</shortLabel>
                                    <fullName>Region 225-260</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15710656" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="225"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="260"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="3173455">
                                <names>
                                    <shortLabel>GST-tag</shortLabel>
                                    <fullName>GST-tag</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15710658" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>gst tag</shortLabel>
                                        <fullName>glutathione s tranferase tag</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">glutathione S-tranferase tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">glutathione S-tranferase tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">gst tag</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0519" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456510" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3173456">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15710654" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3173448</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse</shortLabel>
                                    <fullName>Mus musculus</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
