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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
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                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
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            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
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        </source>
        <experimentList>
            <experimentDescription id="3170559">
                <names>
                    <shortLabel>engel-2008-1</shortLabel>
                </names>
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                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18408164" refType="primary-reference" refTypeAc="MI:0358"/>
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                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-68655X" refType="identity" refTypeAc="MI:0356"/>
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                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
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                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>fluorescence spectr</shortLabel>
                        <fullName>classical fluorescence spectroscopy</fullName>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Engel MF., Khemtémourian L., Kleijer CC., Meeldijk HJ., Jacobs J., Verkleij AJ., de Kruijff B., Killian JA., Höppener JW.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68655X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Engel MF.,  Khemtémourian L.,  Kleijer CC.,  Meeldijk HJ.,  Jacobs J.,  Verkleij AJ.,  de Kruijff B.,  Killian JA.,  Höppener JW.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="3170560">
                <names>
                    <shortLabel>engel-2008-2</shortLabel>
                </names>
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                        <primaryRef db="pubmed" dbAc="MI:0446" id="18408164" refType="primary-reference" refTypeAc="MI:0358"/>
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                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-68656X" refType="identity" refTypeAc="MI:0356"/>
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                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>tem</shortLabel>
                        <fullName>transmission electron microscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">tem</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0020" refType="identity" refTypeAc="MI:0356"/>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Engel MF., Khemtémourian L., Kleijer CC., Meeldijk HJ., Jacobs J., Verkleij AJ., de Kruijff B., Killian JA., Höppener JW.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68656X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Engel MF.,  Khemtémourian L.,  Kleijer CC.,  Meeldijk HJ.,  Jacobs J.,  Verkleij AJ.,  de Kruijff B.,  Killian JA.,  Höppener JW.</attribute>
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                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="3170561">
                <names>
                    <shortLabel>engel-2008-3</shortLabel>
                </names>
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                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18408164" refType="primary-reference" refTypeAc="MI:0358"/>
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                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-68657X" refType="identity" refTypeAc="MI:0356"/>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>3d-em</shortLabel>
                        <fullName>3D electron microscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">3D-EM</alias>
                        <alias typeAc="MI:1041" type="synonym">electron tomog</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0410" refType="identity" refTypeAc="MI:0356"/>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Engel MF., Khemtémourian L., Kleijer CC., Meeldijk HJ., Jacobs J., Verkleij AJ., de Kruijff B., Killian JA., Höppener JW.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68657X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Engel MF.,  Khemtémourian L.,  Kleijer CC.,  Meeldijk HJ.,  Jacobs J.,  Verkleij AJ.,  de Kruijff B.,  Killian JA.,  Höppener JW.</attribute>
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                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3170562">
                <names>
                    <shortLabel>iapp_human</shortLabel>
                    <fullName>Islet amyloid polypeptide</fullName>
                    <alias typeAc="MI:0301" type="gene name">IAPP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Amylin</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Diabetes-associated peptide</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Insulinoma amyloid peptide</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P10997" version="SP_114" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905907" secondary="negative regulation of amyloid fibril formation" version="SP_199"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019233" secondary="sensory perception of pain" version="SP_199"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010942" secondary="positive regulation of cell death" version="SP_199"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_199"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051260" secondary="protein homooligomerization" version="SP_199"/>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-418555" version="SP_199"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL</sequence>
                <attributeList>
                    <attribute name="mimix:comment">not sure about the protein origin</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-9226-2" id="3170563">
                <names>
                    <shortLabel>iapp-6</shortLabel>
                </names>
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                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-59407E" refType="identity" refTypeAc="MI:0356"/>
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                <experimentList>
                    <experimentRef>3170559</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3170564">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15697926" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3170562</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="-1">
                                <names>
                                    <shortLabel>in vitro</shortLabel>
                                    <fullName>In vitro</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-9226-1" id="3170565">
                <names>
                    <shortLabel>iapp-7</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-59407E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9226-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15697938" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3170560</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3170566">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15697942" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3170562</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="-1">
                                <names>
                                    <shortLabel>in vitro</shortLabel>
                                    <fullName>In vitro</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-9226-3" id="3170567">
                <names>
                    <shortLabel>iapp-8</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-59407E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15697954" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9226-3" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3170561</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3170568">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15697958" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3170562</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="-1">
                                <names>
                                    <shortLabel>in vitro</shortLabel>
                                    <fullName>In vitro</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
