<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3170334">
                <names>
                    <shortLabel>brown-2008-3</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18391205" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-68650X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0800478105" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15696729" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9223" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>crosslink</shortLabel>
                        <fullName>cross-linking study</fullName>
                        <alias typeAc="MI:1041" type="synonym">crosslink</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0030" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1049" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>weight autoradiogra</shortLabel>
                        <fullName>molecular weight estimation by autoradiography</fullName>
                        <alias typeAc="MI:1041" type="synonym">weight autoradiogra</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0821" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218638" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Brown MR., Clark KD., Gulia M., Zhao Z., Garczynski SF., Crim JW., Suderman RJ., Strand MR.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68650X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Brown MR.,  Clark KD.,  Gulia M.,  Zhao Z.,  Garczynski SF.,  Crim JW.,  Suderman RJ.,  Strand MR.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3170335">
                <names>
                    <shortLabel>a0ezr6_aedae</shortLabel>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="A0EZR6" version="7" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036438" version="TrEMBL_68"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29909N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="TrEMBL_68"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022352" version="TrEMBL_68"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016179" version="TrEMBL_68"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR022353" version="TrEMBL_68"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005179" secondary="hormone activity" version="TrEMBL_68"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR040228" version="TrEMBL_68"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15696775" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="7159">
                    <names>
                        <shortLabel>aedae</shortLabel>
                        <fullName>Aedes aegypti (Yellowfever mosquito)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Culex aegypti</alias>
                        <alias typeAc="MI:1041" type="synonym">Yellowfever mosquito</alias>
                    </names>
                </organism>
                <sequence>MSSTNLRVSSHLGLGSTMMHWGLMVLMVGTVVQAADQRFCGKQLVLTLSMLCDEFPDLHYGAKKSLNDYDKDYSTDEWLAMIGQDPESIVSTDLMVPHMDQQTVQQQQKVPLWMAMMYPQGYGFRSSASRNDLIPPRFRKSPRGIVDECCLRPCSINQLLKYCKTIA</sequence>
            </interactor>
            <interactor id="3170336">
                <names>
                    <shortLabel>insr_aedae</shortLabel>
                    <fullName>Insulin-like receptor</fullName>
                    <alias typeAc="MI:0301" type="gene name">InR</alias>
                    <alias typeAc="MI:0306" type="orf name">AAEL002317</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q93105" version="71" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006212" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016246" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043559" secondary="insulin binding" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036941" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_156"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29908N"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000494" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008286" secondary="insulin receptor signaling pathway" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043548" secondary="phosphatidylinositol 3-kinase binding" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043560" secondary="insulin receptor substrate binding" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008266" version="SP_156"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15696740" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002011" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036116" version="SP_156"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q17IL5" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005009" secondary="insulin-activated receptor activity" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001245" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003961" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009030" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" secondary="protein autophosphorylation" version="SP_156"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_156"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_001661260.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006211" version="SP_156"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020635" version="SP_156"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="7159">
                    <names>
                        <shortLabel>aedae</shortLabel>
                        <fullName>Aedes aegypti (Yellowfever mosquito)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Culex aegypti</alias>
                        <alias typeAc="MI:1041" type="synonym">Yellowfever mosquito</alias>
                    </names>
                </organism>
                <sequence>MVSLLLFSILVVPVAVVQGDEMKAGQVGPVPKGGVCGSVDVRNSPAHLDRLKDCVVVEGFVHILLIDKYIDSSFENYSFPLLTEITEYLLLFRVNGLKSLRRLFPNLAVIRGDALVGDYAMVIYELMHIEEIGLISLMDITRGGVRIEKNPKLCFANTIDWKAMTVPGTNNYIKDNQKDNVCPICPAESTAVMLPNGSKQKCPAAPVRGGNKDHKRTLCWNANHCQTICPPECPKACSKTGVCCDAESCLGGCNLPNTSSCSVCRHLSIDPAGKRQCVAKCPPNTFKYHTRCVTRDECYAMKKPISLDSNPDLPDQPFIPHNGSCLMECPLDHELITELNKTRWCRKCSGTCPKRCEGSNIDNIQSAQLLKGCEIIDGSLEIQLRSRGGENIVKELENFLSSITEIKGYLKVVRSYPLLSLGFLKKLKIIHGKGNKVSNSSLYVVENQNLQELFDHNVTIGEGKLFFFNNPMLCTDRIKAVKKYNPGIEIENESQLESNNGDRAACSITELETSLKSIGSETAIIQWAPFTELSDARMLLGYVIYYIEAPYANVTFFDGRDACNTEGWRLDDISDFNMDKETTKILTQLKPYTQYAYYVKTYTLGSEGLGGQSKIKYFTTAPGTPSVVRDVEVSVNKNMLTVKWLPPLKMNGRLKEYEVFIELNADDNEQLMLRDYCEDDKLRDIVPETPTSAPPPKTSICTADQCRNYCKAPTSGGSTGTIDVTDKENQITFEDQLHNYVYIKNPLLRDKTTRRKRSTNLLFPNNTENKKNDTTDRRTEKVKDEPYYQYIFNATNETSITFPLSYFNHYSLYVFKIRACRHPGDPPAPSVRLVDVELACGNEVFENFRTPKKEGADDIPPESILIEEQSNNTQRQIRVQWKEPSKPNGPIVKFVVKYQRVDLESVSSTDICIRYSSFNQTRGALLTKLEPGNYSIRVMATTIAGDGAPSAARYVLIAKDDSMGTTLIWLGTLIVIFLCSVGFVAFYWYKYRYMSKQIRMYPEVNPDYAGVQYKVDDWEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLLEASVMKQFNTHHVVRLLGVVSQGDPTLVIMELMANGDLKSYLRRHRPDYENGEDPSPQPPTLRQIIQMAIEIADGMAYLSAKKFVHRDLAARNCMVADDMTVKIGDFGMTRDIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLRYVIDGGVMERPENCPDNLYNLMRRCWQHRPTARPTFMEIISELLPDASPHFQDVAFYNSQDALDMLRGQHQTVIIDEATTPLRPGDDHDEEPGEDDDLVGHGEGHIGDVGTDDEFSMEMTNSHLVRNNGPMATIRSPHSPLR</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-9223-1" id="3170337">
                <names>
                    <shortLabel>a0ezr6_aedae-inr-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-59404E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15696785" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9223-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3170334</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3170338">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15696790" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3170335</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="-1">
                                <names>
                                    <shortLabel>in vitro</shortLabel>
                                    <fullName>In vitro</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3170339">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15696789" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3170336</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="7159">
                                <names>
                                    <shortLabel>aedae</shortLabel>
                                    <fullName>Aedes aegypti (Yellowfever mosquito)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Culex aegypti</alias>
                                    <alias typeAc="MI:1041" type="synonym">Yellowfever mosquito</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
