DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ michishita-2008-1 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Michishita E., McCord RA., Berber E., Kioi M., Padilla-Nash H., Damian M., Cheung P., Kusumoto R., Kawahara TL., Barrett JC., Chang HY., Bohr VA., Ried T., Gozani O., Chua KF. DIP original experiment: DIP-250267X Nature 2008 IMEx SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Michishita E., McCord RA., Berber E., Kioi M., Padilla-Nash H., Damian M., Cheung P., Kusumoto R., Kawahara TL., Barrett JC., Chang HY., Bohr VA., Ried T., Gozani O., Chua KF. Only protein-protein interactions imex curation sir6_human NAD-dependent protein deacetylase sirtuin-6 SIR2-like protein 6 SIRT6 SIR2L6 Regulatory protein SIR2 homolog 6 protein protein human Homo sapiens Human MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS h3k9ac H3K9Ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARTKQTARKSTGGKAPRKQLAK h3k9ac-sirt6-1 3169594 N/A 3169595 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper N/A 3169596 enzyme target enzyme target substrate substrate unspecified role unspecified role in vitro In vitro direct interaction direct interaction false false false