DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ suzuki-2008-6 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Suzuki C., Garces RG., Edmonds KA., Hiller S., Hyberts SG., Marintchev A., Wagner G. DIP original experiment: DIP-68362X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Suzuki C., Garces RG., Edmonds KA., Hiller S., Hyberts SG., Marintchev A., Wagner G. Only protein-protein interactions imex curation suzuki-2008-7 in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Suzuki C., Garces RG., Edmonds KA., Hiller S., Hyberts SG., Marintchev A., Wagner G. DIP original experiment: DIP-68363X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Suzuki C., Garces RG., Edmonds KA., Hiller S., Hyberts SG., Marintchev A., Wagner G. Only protein-protein interactions imex curation pdcd4_human Programmed cell death protein 4 PDCD4 H731 Nuclear antigen H731-like Neoplastic transformation inhibitor protein Protein 197/15a protein protein human Homo sapiens Human MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY if4a1_human Eukaryotic initiation factor 4A-I EIF4A1 EIF4A DDX2A ATP-dependent RNA helicase eIF4A-1 protein protein human Homo sapiens Human MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI pdcd4-eif4a1-2 3168385 N/A 3168387 unspecified role unspecified role bait bait Region 154-449 Region 154-449 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3168388 unspecified role unspecified role prey prey ecolx Escherichia coli direct interaction direct interaction false false false eif4a1-pdcd4-5 3168386 N/A 3168387 unspecified role unspecified role unspecified role unspecified role Region 157-302 Region 157-302 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Region 319-449 Region 319-449 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3168388 unspecified role unspecified role unspecified role unspecified role N-terminal domain 1-244 N-terminal domain 1-244 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false