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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3167545">
                <names>
                    <shortLabel>grubb-2008-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18268347" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-68298X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15684816" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9095" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0712147105" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10029">
                        <names>
                            <shortLabel>crigr</shortLabel>
                            <fullName>Cricetulus griseus (Chinese hamster)</fullName>
                            <alias typeAc="MI:1041" type="synonym">Cricetulus barabensis griseus</alias>
                            <alias typeAc="MI:1041" type="synonym">Chinese hamster</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>molecular sieving</shortLabel>
                        <fullName>molecular sieving</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Gel Filtration</alias>
                        <alias typeAc="MI:0303" type="go synonym">Size Exclusion Chromatography</alias>
                        <alias typeAc="MI:1041" type="synonym">Size Exclusion Chromatography</alias>
                        <alias typeAc="MI:1041" type="synonym">Gel Filtration</alias>
                        <alias typeAc="MI:1041" type="synonym">Sizing column</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0071" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1175" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Grubb JH., Vogler C., Levy B., Galvin N., Tan Y., Sly WS.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68298X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Grubb JH.,  Vogler C.,  Levy B.,  Galvin N.,  Tan Y.,  Sly WS.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3167546">
                <names>
                    <shortLabel>bglr_human</shortLabel>
                    <fullName>Beta-glucuronidase</fullName>
                    <alias typeAc="MI:0301" type="gene name">GUSB</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Beta-G1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P08236" version="SP_122" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2024096" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006102" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019391" secondary="glucuronoside catabolic process" version="SP_219"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2906879" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P08236" version="SP_219"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HN3" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006027" secondary="glycosaminoglycan catabolic process" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_219"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001280034.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2160916" version="SP_219"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96CL9" version="SP_122" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004566" secondary="beta-glucuronidase activity" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006103" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023230" version="SP_219"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6798695" version="SP_219"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001280033.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_219"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000302728" version="SP_219" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001271219.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" secondary="intracellular membrane-bounded organelle" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904813" secondary="ficolin-1-rich granule lumen" version="SP_219"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BHG" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017853" version="SP_219"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000304895" version="SP_219" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043202" secondary="lysosomal lumen" version="SP_219"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000169919" version="SP_219" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005975" secondary="carbohydrate metabolic process" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008979" version="SP_219"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005250354.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2206292" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_219"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4E1F6" version="SP_157" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006104" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_219"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9PCV0" version="SP_157" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006101" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030246" secondary="carbohydrate binding" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036156" version="SP_219"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29724N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035578" secondary="azurophil granule lumen" version="SP_219"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023232" version="SP_219"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_219"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q549U0" version="SP_122" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000172.2"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-9095-1" id="3167547">
                <names>
                    <shortLabel>gusb-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-59195E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-9095-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15684827" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3167545</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3167548">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15684831" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3167546</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10029">
                                <names>
                                    <shortLabel>crigr</shortLabel>
                                    <fullName>Cricetulus griseus (Chinese hamster)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Cricetulus barabensis griseus</alias>
                                    <alias typeAc="MI:1041" type="synonym">Chinese hamster</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
