DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dentin-2007-1 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. DIP original experiment: DIP-255222X Nature 2007 IMEx Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. Only protein-protein interactions imex curation dentin-2007-2 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. DIP original experiment: DIP-255225X Nature 2007 IMEx Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. Only protein-protein interactions imex curation dentin-2007-3 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. DIP original experiment: DIP-255223X Nature 2007 IMEx Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. Only protein-protein interactions imex curation dentin-2007-4 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. DIP original experiment: DIP-255224X Nature 2007 IMEx Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Dentin R., Liu Y., Koo SH., Hedrick S., Vargas T., Heredia J., Yates J., Montminy M. Only protein-protein interactions imex curation crtc2_mouse CREB-regulated transcription coactivator 2 Torc2 Crtc2 Transducer of regulated cAMP response element-binding protein 2 protein protein mouse Mus musculus Mouse MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDARRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLFRLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGGFLDGEMDAKVPAIEENVVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSLSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPTHPPTPKSLQQLPSQACLVQPSGGQPPGRQPHYGALYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESPSTSLVLDPPAFSEGPGFLGSEGSMSGPQDPHVLNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRLQ Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells mint ubiq_mouse Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb Ubc protein protein mouse Mus musculus Mouse MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG cop1_mouse E3 ubiquitin-protein ligase COP1 Cop1 Constitutive photomorphogenesis protein 1 homolog RING finger and WD repeat domain protein 2 RING-type E3 ubiquitin transferase RFWD2 RNF200 Rfwd2 protein protein mouse Mus musculus Mouse MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAASAATLVSGGVAPAAGSGGLGGPGRPVLVAAAVSGSASAGGAVSAGQSRLSCAARPSAGVGGSSSSLGSSSRKRPLLVPLCNGLLNSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDLLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGTSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYGTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALSDGESNVLIAANSQGTIKVLELV ub-crtc2-1 3160875 N/A 3160879 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3160880 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false crtc2-rfwd2-1 3160876 N/A 3160879 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3160881 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human physical association physical association false false false rfwd2-crtc2-1 3160877 N/A 3160879 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3160881 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false rfwd2-crtc2-2 3160878 N/A 3160879 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Q3U182:p.[Val214Ala;Pro215Ala] V214A/P215A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false mouse Mus musculus Mouse N/A 3160881 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false mouse Mus musculus Mouse physical association physical association false false false