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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3155672">
                <names>
                    <shortLabel>hasan-2007-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="17463087" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-261422X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-22816" refType="imex-primary" refTypeAc="MI:0662"/>
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                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15634280" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10116">
                        <names>
                            <shortLabel>rat</shortLabel>
                            <fullName>Rattus norvegicus (Rat)</fullName>
                            <alias typeAc="MI:1041" type="synonym">Rat</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
                    </names>
                    <xref>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Hasan UA., Caux C., Perrot I., Doffin AC., Menetrier-Caux C., Trinchieri G., Tommasino M., Vlach J.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-261422X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2007</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Hasan UA.,  Caux C.,  Perrot I.,  Doffin AC.,  Menetrier-Caux C.,  Trinchieri G.,  Tommasino M.,  Vlach J.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3155673">
                <names>
                    <shortLabel>o08769_rat</shortLabel>
                    <fullName>Cyclin-dependent kinase inhibitor 1B</fullName>
                    <alias typeAc="MI:0301" type="gene name">Cdkn1b</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">p27Kip1</alias>
                    <alias typeAc="MI:0306" type="orf name">rCG_29991</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cyclin-dependent kinase inhibitor p27</alias>
                </names>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                </interactorType>
                <organism ncbiTaxId="10116">
                    <names>
                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Rat</alias>
                    </names>
                </organism>
                <sequence>MSNVRVSNGSPSLERMDARQTEHPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGRYEWQEVERGSLPEFYYRPPRPPKSACKVPAQESLDVSGSRQAVPSIGSQANSEDRHLVDQMPDSSDSPAGLAEQCPGMRKRPAAEDSSSQNKRANRTEENVSDGSPNAGTVEQTPKKPGLRRQT</sequence>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
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            <interactor id="3155674">
                <names>
                    <shortLabel>cdk2_rat</shortLabel>
                    <fullName>Cyclin-dependent kinase 2</fullName>
                    <alias typeAc="MI:0301" type="gene name">Cdk2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cell division protein kinase 2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cdkn2</alias>
                </names>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000307" secondary="cyclin-dependent protein kinase holoenzyme complex" version="SP_162"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051591" secondary="response to cAMP" version="SP_162"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O09136" version="SP_60" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69563"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015030" secondary="Cajal body" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097134" secondary="cyclin E1-CDK2 complex" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030332" secondary="cyclin binding" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097472" secondary="cyclin-dependent protein kinase activity" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097135" secondary="cyclin E2-CDK2 complex" version="SP_162"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032298" secondary="positive regulation of DNA-dependent DNA replication initiation" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051321" secondary="meiotic cell cycle" version="SP_162"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69200"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-69273"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010468" secondary="regulation of gene expression" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000781" secondary="chromosome, telomeric region" version="SP_162"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-847090" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_162"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046686" secondary="response to cadmium ion" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016301" secondary="kinase activity" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000287" secondary="magnesium ion binding" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_162"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-68962"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002088" secondary="lens development in camera-type eye" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031100" secondary="animal organ regeneration" version="SP_162"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_162"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6804116"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10116">
                    <names>
                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Rat</alias>
                    </names>
                </organism>
                <sequence>MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGLPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-22816-1" id="3155675">
                <names>
                    <shortLabel>cdk2-cdkn1b-4</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-196832E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-22816-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15634291" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3155672</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3155676">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15634296" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3155673</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10116">
                                <names>
                                    <shortLabel>rat</shortLabel>
                                    <fullName>Rattus norvegicus (Rat)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Rat</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="3155677">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15634295" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3155674</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10116">
                                <names>
                                    <shortLabel>rat</shortLabel>
                                    <fullName>Rattus norvegicus (Rat)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Rat</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
