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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3152362">
                <names>
                    <shortLabel>medlock-2007-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="17261801" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-260995X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-22719" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="2HRE" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Medlock A., Swartz L., Dailey TA., Dailey HA., Lanzilotta WN.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-260995X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2007</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Substrate interactions with human ferrochelatase.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Medlock A.,  Swartz L.,  Dailey TA.,  Dailey HA.,  Lanzilotta WN.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3152363">
                <names>
                    <shortLabel>hemh_human</shortLabel>
                    <fullName>Ferrochelatase, mitochondrial</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Protoheme ferro-lyase</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Heme synthase</alias>
                    <alias typeAc="MI:0301" type="gene name">FECH</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P22830" version="SP_91" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2PO7" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD3" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046685" secondary="response to arsenic-containing substance" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006783" secondary="heme biosynthetic process" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033659" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4KLA" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019772" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004325" secondary="ferrochelatase activity" version="SP_218"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-189451" version="SP_218"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QD2" version="SP_218"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001012533.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045471" secondary="response to ethanol" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4MK4" version="SP_218"/>
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                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8KA72" version="SP_111" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HCR" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3AQI" version="SP_218"/>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-22719-1" id="3152364">
                <names>
                    <shortLabel>fech-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-196615E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
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                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-22719-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3152362</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3152365">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15620316" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3152363</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
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