DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ qi-2007-3 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260589X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions imex curation qi-2007-4 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260592X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions imex curation qi-2007-5 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260590X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions imex curation qi-2007-6 mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260593X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions imex curation qi-2007-7 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. DIP original experiment: DIP-260591X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Qi H., Moran MM., Navarro B., Chong JA., Krapivinsky G., Krapivinsky L., Kirichok Y., Ramsey IS., Quill TA., Clapham DE. Only protein-protein interactions imex curation ctsr2_mouse Cation channel sperm-associated protein 2 Catsper2 protein protein mouse Mus musculus Mouse MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization mint ctsr1_mouse Cation channel sperm-associated protein 1 Catsper1 protein protein mouse Mus musculus Mouse MDQSSRRDESYHETHPGSLDPSHQSHPHPHPHPTLHRPNQGGVYYDSPQHGMFQQPYQQHGGFHQQNELQHLREFSDSHDNAFSHHSYQQDRAGVSTLPNNISHAYGGSHPLAESQHSGGPQSGPRIDPNHHPHQDDPHRPSEPLSHPSSTGSHQGTTHQQYHERSHHLNPQQNRDHADTISYRSSTRFYRSHAPFSRQERPHLHADHHHEGHHAHSHHGEHPHHKEQRHYHGDHMHHHIHHRSPSASQLSHKSHSTLATSPSHVGSKSTASGARYTFGARSQIFGKAQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDSIFLSIYVLEAVLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALFQDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQMALLKGLEKVKLEQAARVHEKLLDDSLTDLNKADANAQMTEEALKMQLIEGMFGNMTVKQRVLHFQFLQLVAAVEQHQQKFRSQAYVIDELVDMAFEAGDDDYGK ctsr3_mouse Cation channel sperm-associated protein 3 Catsper3 protein protein mouse Mus musculus Mouse MSQHFHHNPVRVKSGSLFATASEALQARLSKIKRKDKECQAYFRKVIKSTFFQIVMITTVTTNSFLLVLGTNYDIQFEFFRTFEVSELFFVSVYVCEFLMKVYVDPITYWKDGYNILDVIILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFGVTDRGDLENWGNLASAFFTLFSLATVDGWTDLQEELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSMKKFERDLTLERNLAIMEEKQIILKRQQEEVNRLMNTQKSGSMNFIDMVEGFKKTLRHTDPMVLDDFSTSLSFIDIYLVTLDNQDVIVSKLQELYCEIVNVLSLMLEDMPKESSSSLSGLS ctsr4_mouse Cation channel sperm-associated protein 4 Catsper4 protein protein mouse Mus musculus Mouse MSEKHKWWQQVENIDITHLGPKRKAYELLGRHEEQVLINRRDVMEKKDAWDVQEFITQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFSTIDDIVLTILICEVLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEARKDTSTVPKEPLVGGPLSNLTEKTCDNFCLVLEAIQENLMEYKEIREELNMIVEEVSSIRFNQEQQNVILHKYTSKSATFLSEPPEGANKQDLITALVSREKVSDSNINMVNKHKFSH catsper2-catsper1-1 3152130 N/A 3152135 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3152136 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false catsper1-catsper3-1 3152131 N/A 3152137 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3152136 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false catsper3-catsper1-1 3152132 N/A 3152137 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3152136 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false catsper1-catsper4-1 3152133 N/A 3152138 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3152136 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association false false false catsper4-catsper1-1 3152134 N/A 3152138 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3152136 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false