DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ sadowski-2006-1 in vitro In vitro solid phase assay solid phase assay predetermined predetermined participant predetermined Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-264212X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T., Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T. Only protein-protein interactions imex curation sadowski-2006-2 in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-264213X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T., Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T. Only protein-protein interactions imex curation sadowski-2006-3 in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-264214X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T., Sadowski MJ., Pankiewicz J., Scholtzova H., Mehta PD., Prelli F., Quartermain D., Wisniewski T. Only protein-protein interactions imex curation apoe_human Apolipoprotein E APOE protein protein human Homo sapiens Human MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH p05067-pro_0000000093 Amyloid-beta protein 40 APP A4 AD1 ABPP Alzheimer disease amyloid protein Cerebral vascular amyloid peptide PreA4 Protease nexin-II APPI Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV 672 711 app-apoe-1 3150722 N/A 3150725 unspecified role unspecified role prey prey mouse Mus musculus Mouse N/A 3150726 unspecified role unspecified role bait bait Region 12-28 Region 12-28 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction false false false Fig. 1 apoe-app-2 3150723 N/A 3150725 unspecified role unspecified role unspecified role unspecified role mouse Mus musculus Mouse N/A 3150726 unspecified role unspecified role unspecified role unspecified role chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction false false false app-app-75 3150724 N/A 3150726 unspecified role unspecified role unspecified role unspecified role chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3150726 unspecified role unspecified role unspecified role unspecified role chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction false false false