DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ renatus-2006-1 in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. DIP original experiment: DIP-66341X Structure (London, England : 1993) 2006 IMEx Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. Only protein-protein interactions imex curation renatus-2006-2 in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. DIP original experiment: DIP-66343X Structure (London, England : 1993) 2006 IMEx Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. Only protein-protein interactions imex curation renatus-2006-3 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. DIP original experiment: DIP-66342X Structure (London, England : 1993) 2006 IMEx Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Renatus M., Parrado SG., D'Arcy A., Eidhoff U., Gerhartz B., Hassiepen U., Pierrat B., Riedl R., Vinzenz D., Worpenberg S., Kroemer M. Only protein-protein interactions imex curation q5u5u6_human UBB HEL-S-50 hCG_1998947 protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC uchl3_human Ubiquitin carboxyl-terminal hydrolase isozyme L3 Ubiquitin thioesterase L3 UCHL3 protein protein human Homo sapiens Human MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA ubp2_human Ubiquitin carboxyl-terminal hydrolase 2 Ubiquitin-specific-processing protease 2 Deubiquitinating enzyme 2 41 kDa ubiquitin-specific protease USP2 UBP41 Ubiquitin thioesterase 2 protein protein human Homo sapiens Human MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM ubiq_bovin Ubiquitin RPS27A UBA80 UBCEP1 UBA52 UBCEP2 UBB UBC protein protein bovin Bos taurus (Bovine) Bovine MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG ubb-uchl3-1 3146865 N/A 3146868 enzyme target enzyme target substrate substrate unspecified role unspecified role region 1-76 region 1-76 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3146869 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false ubb-usp2-1 3146866 N/A 3146870 enzyme enzyme unspecified role unspecified role Region 259-605 Region 259-605 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3146868 enzyme target enzyme target substrate substrate unspecified role unspecified role region 1-76 region 1-76 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false sigma u6253-usp2-1 3146867 N/A 3146871 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3146870 unspecified role unspecified role unspecified role unspecified role Region 259-605 Region 259-605 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false