DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ oldham-2006-1 in vitro In vitro enzymatic study enzymatic study predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66516X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions imex curation oldham-2006-2 in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66517X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions imex curation oldham-2006-3 in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66518X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions imex curation oldham-2006-4 in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. DIP original experiment: DIP-66519X Nature structural & molecular biology 2006 IMEx Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Oldham WM., Van Eps N., Preininger AM., Hubbell WL., Hamm HE. Only protein-protein interactions imex curation opsd_bovin Rhodopsin RHO protein protein bovin Bos taurus (Bovine) Bovine MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA mint Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal gbg1_bovin Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Transducin gamma chain protein protein bovin Bos taurus (Bovine) Bovine MPVINIEDLTEKDKLKMEVDQLKKEVTLERMLVSKCCEEFRDYVEERSGEDPLVKGIPEDKNPFKELKGGCVIS Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction mint gnat1_bovin Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 Transducin alpha-1 chain protein protein bovin Bos taurus (Bovine) Bovine MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase mint gbb1_bovin Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Transducin beta chain 1 protein protein bovin Bos taurus (Bovine) Bovine MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN gnat1-gnb1-3 3146593 N/A 3146597 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine N/A 3146598 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine N/A 3146599 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli N/A 3146600 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine physical association physical association false false false gnat1-gnb1-4 3146594 N/A 3146597 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine N/A 3146598 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine N/A 3146599 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli N/A 3146600 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine physical association physical association false false false gnat1-rho-1 3146595 N/A 3146597 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine N/A 3146599 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli physical association physical association false false false gnat1-rho-2 3146596 N/A 3146597 unspecified role unspecified role neutral component neutral component bovin Bos taurus (Bovine) Bovine N/A 3146599 unspecified role unspecified role neutral component neutral component ecolx Escherichia coli physical association physical association false false false