DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ tang-2006-15 ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Tang Y., Kim CY., Mathews II., Cane DE., Khosla C. DIP original experiment: DIP-263414X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Tang Y., Kim CY., Mathews II., Cane DE., Khosla C. Only protein-protein interactions imex curation erya3_sacer 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6 eryA 6-deoxyerythronolide B synthase III Erythronolide synthase ORF C protein protein sacer Saccharopolyspora erythraea Streptomyces erythraeus MSGDNGMTEEKLRRYLKRTVTELDSVTARLREVEHRAGEPIAIVGMACRFPGDVDSPESFWEFVSGGGDAIAEAPADRGWEPDPDARLGGMLAAAGDFDAGFFGISPREALAMDPQQRIMLEISWEALERAGHDPVSLRGSATGVFTGVGTVDYGPRPDEAPDEVLGYVGTGTASSVASGRVAYCLGLEGPAMTVDTACSSGLTALHLAMESLRRDECGLALAGGVTVMSSPGAFTEFRSQGGLAADGRCKPFSKAADGFGLAEGAGVLVLQRLSAARREGRPVLAVLAGSAVNQDGASNGLTAPSGPAQQRVIRRALENAGVRAGDVDYVEAHGTGTRLGDPIEVHALLSTYGAERDPDDPLWIGSVKSNIGHTQAAAGVAGVMKAVLALRHGEMPRTLHFDEPSPQIEWDLGAVSVVSQARSWPAGERPRRAGVSSFGISGTNAHVIVEEAPEADEPEPAPDSGPVPLVLSGRDEQAMRAQAGRLADHLAPEPRNSLRDTGFTLATRASAMEHRAVVVGDRDEALAGLRAVADRRIADRTATGQGPNSPRRVAMVFPGQGAQWQGMARDLLRESQVFADSIRDCERALAPHVDWSLTDLLSGARPLDRVDVVQPALFAVMVSLAALWRSHGVEPAAVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIGRFAGALSIASVNGPRSVVVVAGESGPLDELIAECEAEAHKARRIPVDYASHSPQVESLREELLTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAFVEVSPHPVLTVGIEATLDSALPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVDWSPAFADARPVELPVYPFQRYWLPIPTGGRARDEDDDWRYQVVWREAEWESASLAGRVLLVTGPGVPSELSDAIRSGLEQSGATVLTCDVESRSTIGTALEAADTDALSTVGVAAVPHGEAVDPSLDALALVQALGAAGVEAPLWVLTRNAVQVADGELVDPAQAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSLAAVLADPRGEEQVAIRADGIKVARLVPAPARARTHPLEPLAGTVLVTGGTGGIGAHLARWLARSGAEHLVLLGRRGADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAEAAAEGRTVSAVMHAAGVSTSTPLDDLTEAEFTEIADVKVRGTVNLDELCPDLDAFVLFSSNAGVWGSPGLASYAAANAFLDGFARAARSEGAPVTSIAWGLWAGQNMAGDEGGEYLRSQGLRAMDPDRAVEELHITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFDEIAGARAEARQSEEGPALAQRLAALLCDGREREHLAHLIRAEVAAVLGHGDDAAIDRDRAFRDLGFDSMTAVDLRNRLAAVTGVREAATVVFDHPTITRLADHYLERLVGAAEAEQAPALVREVPPKDADDPIAIVGMACRFPGGVHNPGELWEFIVGGGDAVTEMPTDRGWDLDALFDPDPQRHGTSYSRHGAFLDGAADFDAAFFGISPREALAMDPQQRQVLETTWELFENAGIDPHSVRGSDTGVFLGAAYQGYGQDAVVPEDSEGYLLTGNSSAVVSGRVAYVLGLEGPAVTVDTACSSSLVALHSACGSLRDGDCGLAVAGGVSVMAGPEVFTEFSRQGGLAVDGRCKAFSAEADGFGLPEGVAVVQLQRLSDGPAEGGRQVLGVVAGSAINQDGATNGLAAPSGVAQQRVIRKAWARAGITGADVAVVEAHGTGTRLGDPVEASALLATYGKSRGSSGPVLLGSVKSNIGHAQAAAGVAGVIKVVLGLNRGLVPPMLCRGERSPLIEWSSGGVELAEAVSPWPPAADGVRRAGVSAFGVSGTNAHVIIAEPPEPEPLPEPGPVGVLAAANSVPVLLSARTETALAAQARLLESAVDDSVPLTALASALATGRAHLPRRAALLAGDHEQLRGQLRAVAEGVAAPGATTGTASAGGVVFVFPGQGAQWEGMARGLLSVPVFAESIAECDAVLSEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSAVIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPWEDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETILADLDGISARRAAIPLYSTLHGERRDMGPRYWYDNLRSQVRFDEAVSAQSPDGHATFVEMSPHPVLTAAVQEIAADAVAIGSLHRDTAEEHLIAELARAHVHGVAVDWRNVFPAAPPVALPNYPFEPQRYWLAPEVSDQLADSRYRVDWRPLATTPVDLEGGFLVHGSAPESLTSAVEKAGGVVPVASADREALAAALREVPGEVAGVLSVHTGAANALALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGLETPERWGGLVDLPAEPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTRESSWEPAGTALVTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPAAAELEAELVALGPKTTITACDVADREQLSKLLEELRGQGRPVRTVVHTAGVPESRPLHEIGELESVCAAKVTGARLLDELCPDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGRAATSVAWGAWAGEGMATGDLEGLTRRGLRPMAPDRAIRALHQALDNGDTCVSIADVDWEAFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQELLEFTHSHVAAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATGLALPATLVFEHPTVRRLADHIGQQLDSGTPAREASSALRDGYRQAGVSGRVRSYLDLLAGLSDFREHFDGSDGFSLDLVDMADGPGEVTVICCAGTAAISGPHEFTRLAGALRGIAPVRAVPQPGYEEGEPLPSSMAAVAAVQADAVIRTQGDKPFVVAGHSAGALMAYALATELLDRGHPPRGVVLIDVYPPGHQDAMNAWLEELTATLFDRETVRMDDTRLTALGAYDRLTGQWRPRETGLPTLLVSAGEPMGPWPDDSWKPTWPFEHDTVAVPGDHFTMVQEHADAIARHIDAWLGGGNS erya-1 3145822 N/A 3145823 unspecified role unspecified role unspecified role unspecified role Region 1-917 Region 1-917 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli direct interaction direct interaction false false false