<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3136524">
                <names>
                    <shortLabel>krojer-2002-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="11919638" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="1KY9" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15528374" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24283" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-265077X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/416455a" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>interaction detect</shortLabel>
                        <fullName>interaction detection method</fullName>
                        <alias typeAc="MI:1041" type="synonym">interaction detect</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0001" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-705620" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Krojer T., Garrido-Franco M., Huber R., Ehrmann M., Clausen T.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-265077X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2002</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Krojer T.,  Garrido-Franco M.,  Huber R.,  Ehrmann M.,  Clausen T.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3136525">
                <names>
                    <shortLabel>degp_ecoli</shortLabel>
                    <fullName>Periplasmic serine endoprotease DegP</fullName>
                    <alias typeAc="MI:0301" type="gene name">degP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">htrA</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ptd</alias>
                    <alias typeAc="MI:0305" type="locus name">b0161</alias>
                    <alias typeAc="MI:0305" type="locus name">JW0157</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Heat shock protein DegP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protease Do</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P0C0V0" version="SP_25" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CS0" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OTP" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MH5" version="SP_141"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-547165" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensemblbacteria" id="BAB96738" version="SP_141" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001940" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009408" secondary="response to heat" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030288" secondary="outer membrane-bounded periplasmic space" version="SP_141"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036034" version="SP_141"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-46256N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008236" secondary="serine-type peptidase activity" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OU0" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JJL" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009266" secondary="response to temperature stimulus" version="SP_141"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="WP_000753946.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MH6" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A8D" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KY9" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JJO" version="SP_141"/>
                    <secondaryRef db="ensemblbacteria" id="AAC73272" version="SP_141" refType="transcript"/>
                    <secondaryRef db="ensemblbacteria" id="b0161" version="SP_141" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006515" secondary="protein quality control for misfolded or incompletely synthesized proteins" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008233" secondary="peptidase activity" version="SP_141"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P09376" version="SP_25" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P15724" version="SP_25" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009003" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2ZLE" version="SP_141"/>
                    <secondaryRef db="ensemblbacteria" id="BAB96738" version="SP_141" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MH7" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JJK" version="SP_141"/>
                    <secondaryRef db="ensemblbacteria" id="BAB96738" version="SP_141" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006508" secondary="proteolysis" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004252" secondary="serine-type endopeptidase activity" version="SP_141"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011782" version="SP_141"/>
                    <secondaryRef db="ensemblbacteria" id="AAC73272" version="SP_141" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006979" secondary="response to oxidative stress" version="SP_141"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061077" secondary="chaperone-mediated protein folding" version="SP_141"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_414703.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006457" secondary="protein folding" version="SP_141"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001478" version="SP_141"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MH4" version="SP_141"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="83333">
                    <names>
                        <shortLabel>ecoli</shortLabel>
                        <fullName>Escherichia coli (strain K12)</fullName>
                    </names>
                </organism>
                <sequence>MKKTTLALSALALSLGLALSPLSATAAETSSATTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDSPFCQEGSPFQSSPFCQGGQGGNGGGQQQKFMALGSGVIIDADKGYVVTNNHVVDNATVIKVQLSDGRKFDAKMVGKDPRSDIALIQIQNPKNLTAIKMADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNAENYENFIQTDAAINRGNSGGALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVLPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKLTLGLLRDGKQVNVNLELQQSSQNQVDSSSIFNGIEGAEMSNKGKDQGVVVNNVKTGTPAAQIGLKKGDVIIGANQQAVKNIAELRKVLDSKPSVLALNIQRGDSTIYLLMQ</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-24283-1" id="3136526">
                <names>
                    <shortLabel>degp-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-88172E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15528386" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24283-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3136524</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3136527">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15528390" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3136525</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3136528">
                                <names>
                                    <shortLabel>P0C0V0:p.Ser236Ala</shortLabel>
                                    <fullName>S236A mutation</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15528391" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation</shortLabel>
                                        <fullName>mutation</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0118" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456558" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>predetermined featur</shortLabel>
                                        <fullName>predetermined feature</fullName>
                                        <alias typeAc="MI:1041" type="synonym">predetermined featur</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0823" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218592" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="236"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="236"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
