<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3135332">
                <names>
                    <shortLabel>lamers-2000-1</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="11048711" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-265107X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24294" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="wwpdb" dbAc="MI:0805" id="1E3M" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/35037523" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15489908" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Lamers MH., Perrakis A., Enzlin JH., Winterwerp HH., de Wind N., Sixma TK.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-265107X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2000</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Lamers MH.,  Perrakis A.,  Enzlin JH.,  Winterwerp HH.,  de Wind N.,  Sixma TK.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3135333">
                <names>
                    <shortLabel>muts_ecoli</shortLabel>
                    <fullName>DNA mismatch repair protein MutS</fullName>
                    <alias typeAc="MI:0301" type="gene name">mutS</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">fdv</alias>
                    <alias typeAc="MI:0305" type="locus name">b2733</alias>
                    <alias typeAc="MI:0305" type="locus name">JW2703</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P23909" version="SP_70" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-10287N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1W7A" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1WB9" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036187" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7AIC" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032300" secondary="mismatch repair complex" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1WBB" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2WTU" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016151" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1WBD" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008301" secondary="DNA binding, bending" version="SP_179"/>
                    <secondaryRef db="ensemblbacteria" id="BAE76810" version="SP_179" refType="transcript"/>
                    <secondaryRef db="ensemblbacteria" id="BAE76810" version="SP_179" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043531" secondary="ADP binding" version="SP_179"/>
                    <secondaryRef db="ensemblbacteria" id="b2733" version="SP_179" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AKB" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6I5F" version="SP_179"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_417213.1"/>
                    <secondaryRef db="ensemblbacteria" id="AAC75775" version="SP_179" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1E3M" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR027417" version="SP_179"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2MA96" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensemblbacteria" id="BAE76810" version="SP_179" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7AIB" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1OH5" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000432" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000018" secondary="regulation of DNA recombination" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1OH7" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007861" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003684" secondary="damaged DNA binding" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030983" secondary="mismatched DNA binding" version="SP_179"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P71279" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1OH6" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OK2" version="SP_179"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-554920" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032136" secondary="adenine/cytosine mispair binding" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005748" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017261" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" secondary="cellular response to DNA damage stimulus" version="SP_179"/>
                    <secondaryRef db="ensemblbacteria" id="AAC75775" version="SP_179" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008094" secondary="ATPase, acting on DNA" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7AI7" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1NG9" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3K0S" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AKC" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007695" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1OH8" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7AI6" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3ZLJ" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036678" version="SP_179"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006298" secondary="mismatch repair" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007860" version="SP_179"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR007696" version="SP_179"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AKD" version="SP_179"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="WP_001272928.1"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="83333">
                    <names>
                        <shortLabel>ecoli</shortLabel>
                        <fullName>Escherichia coli (strain K12)</fullName>
                    </names>
                </organism>
                <sequence>MSAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLSVPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-24294-1" id="3135334">
                <names>
                    <shortLabel>muts-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-18038E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15489920" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24294-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>3135332</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3135335">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15489924" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3135333</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3135336">
                                <names>
                                    <shortLabel>1-800 Binding region</shortLabel>
                                    <fullName>1-800 Binding region</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15489925" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>predetermined featur</shortLabel>
                                        <fullName>predetermined feature</fullName>
                                        <alias typeAc="MI:1041" type="synonym">predetermined featur</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0823" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218592" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="800"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
