MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint alam-2016-1 in vitro In vitro elisa enzyme linked immunosorbent assay ELISA ELISA elisa antibody detection identification by antibody antibody detection Alam MS., Rathore S., Tyagi RK., Sharma YD. ydsharma_aiims@yahoo.com FEBS letters 2016 Only protein-protein interactions imex curation imex curation alam-2016-2 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Alam MS., Rathore S., Tyagi RK., Sharma YD. ydsharma_aiims@yahoo.com FEBS letters 2016 Only protein-protein interactions imex curation imex curation b3at_human Band 3 anion transport protein SLC4A1 AE1 DI EPB3 Anion exchange protein 1 Solute carrier family 4 member 1 protein protein human Homo sapiens Human MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590] Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin mint Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal a5k5e5_plavs PVX_088820 protein protein Plasmodium vivax (strain Salvador I) Plasmodium vivax (strain Salvador I) MELKKNNAALTSQRSSSRTTSTRSYKNAPKNSTSFLSRLSILIFALSCAIFVNTASGAAANRPNANGFVSPTLIGFGELSIQESEEFKRMAWNNWMLRLESDWKHFNDSVEEAKTKWLHERDSAWSDWLRSLQSKWSHYSEKMLKEHKSNVMEKSANWNDTQWGNWIKTEGRKILEAQWEKWIKKGDDQLQKLILDKWVQWKNDKIRSWLSSEWKTEEDYYWANVERATTAKWLQEAEKMHWLKWKERINRESEQWVNWVQMKESVYINVEWKKWPKWKNDKKILFNKWSTNLVYKWTLKKQWNVWIKEANTAPQV slc4a1-a5k5e5_plavs-1 1924638 N/A 1924640 predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified N/A 1924641 unspecified role unspecified role prey prey purified purified his tag his tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.[Lys197Ala;Trp198Ala;Val199Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.[Gln200Ala;Trp201Ala;Lys202Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.[Asn203Ala;Asp204Ala;Lys205Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.[Ile206Ala;Arg207Ala;Ser208Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.[Ser212Ala;Glu213Ala;Trp214Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false t1 slc4a1-a5k5e5_plavs-2 1924638 N/A 1924640 predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified N/A 1924641 unspecified role unspecified role prey prey purified purified his tag his tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false t2 slc4a1-a5k5e5_plavs-3 1924638 N/A 1924640 unspecified role unspecified role prey prey purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false trx tag tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1924641 predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false f2a a5k5e5_plavs-slc4a1-1 1924638 N/A 1924640 unspecified role unspecified role prey prey purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false trx tag tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1924641 predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified A5K5E5:p.Lys197Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false f2b a5k5e5_plavs-slc4a1-2 1924638 N/A 1924640 unspecified role unspecified role prey prey purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false trx tag tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1924641 predetermined predetermined participant predetermined unspecified role unspecified role bait bait purified purified A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false f2c a5k5e5_plavs-slc4a1-3 1924639 N/A 1924640 unspecified role unspecified role bait bait purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false N/A 1924641 unspecified role unspecified role prey prey purified purified A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Trp201Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Trp198Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false 1924639 t3 slc4a1-a5k5e5_plavs-4 1924639 N/A 1924640 unspecified role unspecified role bait bait purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false N/A 1924641 unspecified role unspecified role prey prey purified purified A5K5E5:p.Lys197Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false 1924639 t3 slc4a1-a5k5e5_plavs-5 1924639 N/A 1924640 unspecified role unspecified role bait bait purified purified range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false N/A 1924641 unspecified role unspecified role prey prey purified purified A5K5E5:p.Gln200Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false range binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Val199Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Arg207Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Asn203Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Lys202Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false A5K5E5:p.Lys205Ala mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false 1924639 t3