HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html http://www.agbase.msstate.edu/hpi/main.html chaudhary-2012-1 human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. split luciferase complementation split luciferase complementation predetermined predetermined participant predetermined Chaudhary A., Ganguly K., Cabantous S., Waldo GS., Micheva-Viteva SN., Nag K., Hlavacek WS., Tung CS. anuc@u.washington.edu, anuc@uw.edu Biochemical and biophysical research communications 2012 imex curation Only protein-protein interactions imex curation myd88_human Myeloid differentiation primary response protein MyD88 MYD88 protein protein human Homo sapiens Human MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP q8yf33_brume BMEI1694 protein protein brume Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) MNIHASNLDIEKFRKVYALVTGGATDGERVAAQARARKIAERAGMSLNDAVSQLDSQPKPKPANFFEGFADWMEEKEPGYKAKRAREVVEREQRYASRRAEILKQFGTAKAFLDPTPNERLILKAAEPFIAELGEPYEDACGTWRRPISSFAGVHSHFFNLDDVDPEAIMAIKAAIPFPETICGAFEELKVWDKLNDDRAHFYGHHEYYYELPVELRIELLREVMRTQPVTSWGDLEARFHYKSYAWQRQWIDPKDFDDPEWSRLFDDVRILRALAEKPFREPVQNGRRTNAEKRSAVLSMLDTNPELSDREICRRVGVSPKTVGNWRRRRNDRLSQP tirap_human Toll/interleukin-1 receptor domain-containing adapter protein MyD88 adapter-like protein Adaptor protein Wyatt TIRAP MAL protein protein human Homo sapiens Human MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLS tcpb-myd88-1 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false N/A 1900218 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false 1B tcpb-tirap-1 1900216 N/A 1900219 unspecified role unspecified role neutral component neutral component c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false N/A 1900218 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false 1B myd88-myd88-9 1900216 N/A 1900217 inhibitor inhibitor unspecified role unspecified role TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false 1900239 1900235 physical association physical association false false false 3B-B1 only MyD88DD and MyD88 can inhibit the homodimerization of full-length MyD88 myd88-myd88-11 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false 1900247 1900242 physical association physical association false false false 3B-D1 myd88-myd88-12 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role 1900254 1900252 physical association physical association false false false 3B-C1 myd88-myd88-4 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1900217 unspecified role unspecified role neutral component neutral component c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false 3A-1 myd88-myd88-5 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false 3A-2 myd88-myd88-6 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1900217 unspecified role unspecified role neutral component neutral component c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false 3A-3 weak interaction myd88-myd88-7 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false 1900279 1900277 physical association physical association false false false 3A-4 myd88-myd88-14 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false 1900286 1900283 physical association physical association false false false 3A-5 weak interaction myd88-myd88-15 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false 1900293 1900291 physical association physical association false false false 3A-6 myd88-myd88-16 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false 3A-7 myd88-myd88-17 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component n terminus gaussia-n gaussia-n gaussia-n n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false c terminus gaussia-c gaussia-c gaussia-c c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false 3A-8 myd88-myd88-18 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900218 inhibitor inhibitor unspecified role unspecified role 1900312 1900310 physical association physical association false false false 3BA-2 TcpB does not significantly perturb homodimerization of full-length MyD88 but it disrupts homo- and heterotypic interactions mediated by the DD of MyD88. only MyD88DD and MyD88 can inhibit the Homodimerization of full-length MyD88 myd88-myd88-19 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900218 inhibitor inhibitor unspecified role unspecified role 1900321 1900318 physical association physical association false false false 3BA-3 TcpB does not significantly perturb homodimerization of full-length MyD88 but it disrupts homo- and heterotypic interactions mediated by the DD of MyD88. only MyD88DD and MyD88 can inhibit the Homodimerization of full-length MyD88 myd88-myd88-20 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900218 stimulator stimulator unspecified role unspecified role physical association physical association false false false 3BA-4 myd88-myd88-10 1900216 N/A 1900217 inhibitor inhibitor unspecified role unspecified role TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false 1900337 1900334 physical association physical association false false false 3B-B2 myd88-myd88-22 1900216 N/A 1900217 inhibitor inhibitor unspecified role unspecified role TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false 1900346 1900341 physical association physical association false false false 3B-B4 myd88-myd88-23 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role 1900352 1900350 physical association physical association false false false 3B-C2 myd88-myd88-24 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role physical association physical association false false false 3B-C3 only MyD88DD and MyD88 can inhibit the homodimerization of full-length MyD88 myd88-myd88-25 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role physical association physical association false false false 3B-C4 only MyD88DD and MyD88 can inhibit the homodimerization of full-length MyD88 myd88-myd88-26 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false 1900375 1900370 physical association physical association false false false 3B-D2 only MyD88DD and MyD88 can inhibit the homodimerization of full-length MyD88 myd88-myd88-27 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 3B-D3 only MyD88DD and MyD88 can inhibit the homodimerization of full-length MyD88 myd88-myd88-28 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 3B-D4 myd88-myd88-29 1900216 N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 inhibitor inhibitor unspecified role unspecified role DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 3B-D5 only MyD88DD and MyD88 can inhibit the homodimerization of full-length MyD88 myd88-myd88-30 1900216 N/A 1900217 inhibitor inhibitor unspecified role unspecified role TIR sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 1900217 unspecified role unspecified role neutral component neutral component gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1900217 unspecified role unspecified role neutral component neutral component DD sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false gaussia_tag tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 3B-B3i